Emerging and re-emerging warheads for targeted covalent inhibitors: an update

L Hillebrand, XJ Liang, RAM Serafim… - Journal of medicinal …, 2024 - ACS Publications
Covalent inhibitors and other types of covalent modalities have seen a revival in the past two
decades, with a variety of new targeted covalent drugs having been approved in recent …

Challenges and opportunities in cancer drug resistance

RA Ward, S Fawell, N Floc'h, V Flemington… - Chemical …, 2020 - ACS Publications
There has been huge progress in the discovery of targeted cancer therapies in recent years.
However, even for the most successful and impactful cancer drugs which have been …

[BOG][B] Principles of animal nutrition

G Wu - 2017 - taylorfrancis.com
Animals are biological transformers of dietary matter and energy to produce high-quality
foods and wools for human consumption and use. Mammals, birds, fish, and shrimp require …

[BOG][B] Amino acids: biochemistry and nutrition

G Wu - 2021 - taylorfrancis.com
Following its predecessor, the second edition of Amino Acids: Biochemistry and Nutrition
presents exhaustive coverage of amino acids in the nutrition, metabolism and health of …

Breast milk: A source of functional compounds with potential application in nutrition and therapy

C Sánchez, L Franco, P Regal, A Lamas, A Cepeda… - Nutrients, 2021 - mdpi.com
Breast milk is an unbeatable food that covers all the nutritional requirements of an infant in
its different stages of growth up to six months after birth. In addition, breastfeeding benefits …

Superoxide dismutase 1 in health and disease: how a frontline antioxidant becomes neurotoxic

BG Trist, JB Hilton, DJ Hare, PJ Crouch… - Angewandte Chemie …, 2021 - Wiley Online Library
Cu/Zn superoxide dismutase (SOD1) is a frontline antioxidant enzyme catalysing superoxide
breakdown and is important for most forms of eukaryotic life. The evolution of aerobic …

Revised reference values for the intake of protein

M Richter, K Baerlocher, JM Bauer, I Elmadfa… - Annals of Nutrition and …, 2019 - karger.com
Background: Following a timely update process, the nutrition societies of Germany, Austria,
and Switzerland (DA-CH) revised the reference values for the intake of protein in 2017. The …

The many models of strigolactone signaling

M Bürger, J Chory - Trends in plant science, 2020 - cell.com
Strigolactones (SLs) are a class of plant hormones involved in several biological processes
that are of great agricultural concern. While initiating plant–fungal symbiosis, SLs also …

Beyond metabolic waste: lysine lactylation and its potential roles in cancer progression and cell fate determination

J Wang, L Mao, J Wang, X Zhang, M Wu, Q Wen, S Yu - Cellular Oncology, 2023 - Springer
Background Lactate is an important metabolite derived from glycolysis under physiological
and pathological conditions. The Warburg effect reveals the vital role of lactate in cancer …

Directed evolution 2.0: improving and deciphering enzyme properties

F Cheng, L Zhu, U Schwaneberg - Chemical Communications, 2015 - pubs.rsc.org
Directed evolution has matured to a routinely applied algorithm to tailor enzyme properties
to meet the demands in various applications. In order to free directed enzyme evolution from …