Secretion of pro-oncogenic AGR2 protein in cancer

NA Moidu, NSA Rahman, SE Syafruddin, TY Low… - Heliyon, 2020 - cell.com
Abstract Anterior gradient-2 (AGR2) protein mediates the formation, breakage and
isomerization of disulphide bonds during protein maturation in the endoplasmic reticulum …

The prognostic value of AGR2 expression in solid tumours: a systematic review and meta-analysis

S Tian, K Tao, J Hu, Z Liu, X Ding, Y Chu, J Cui… - Scientific reports, 2017 - nature.com
The prognostic value of anterior gradient-2 (AGR2) in tumours remains inconclusive. Here,
we systematically reviewed the literature evidence and assessed the association between …

Circulating tumour cells from patients with colorectal cancer have cancer stem cell hallmarks in ex vivo culture

F Grillet, E Bayet, O Villeronce, L Zappia, EL Lagerqvist… - Gut, 2017 - gut.bmj.com
Objective Although counting of circulating tumour cells (CTC) has attracted a broad interest
as potential markers of tumour progression and treatment response, the lack of functional …

miR-342-3p suppresses cell proliferation and migration by targeting AGR2 in non-small cell lung cancer

X Xue, X Fei, W Hou, Y Zhang, L Liu, R Hu - Cancer letters, 2018 - Elsevier
AGR2 is a well-studied secreted protein that is involved in multiple biological processes
including cell proliferation and migration. The mechanism by which AGR2 increases the …

Identification of novel gene expression signature in lung adenocarcinoma by using next-generation sequencing data and bioinformatics analysis

YL Hsu, JY Hung, YL Lee, FW Chen, KF Chang… - …, 2017 - pmc.ncbi.nlm.nih.gov
Lung adenocarcinoma is one of the leading causes of cancer-related death worldwide. We
showed transcriptomic profiles in three pairs of tumors and adjacent non-tumor lung tissues …

[HTML][HTML] FOXM1 activates AGR2 and causes progression of lung adenomas into invasive mucinous adenocarcinomas

D Milewski, D Balli, V Ustiyan, T Le, H Dienemann… - PLoS …, 2017 - journals.plos.org
Lung cancer remains one of the most prominent public health challenges, accounting for the
highest incidence and mortality among all human cancers. While pulmonary invasive …

Unraveling the impact of cancer-associated fibroblasts on hypovascular pancreatic neuroendocrine tumors

TY Lai, TC Chiang, CY Lee, TC Kuo, CH Wu… - British Journal of …, 2024 - nature.com
Abstract Background Pancreatic neuroendocrine tumors (PNETs) with low microvessel
density and fibrosis often exhibit clinical aggressiveness. Given the contribution of cancer …

Distinct signatures of lung cancer types: aberrant mucin O-glycosylation and compromised immune response

M Lucchetta, I da Piedade, M Mounir, M Vabistsevits… - BMC cancer, 2019 - Springer
Background Genomic initiatives such as The Cancer Genome Atlas (TCGA) contain data
from-omics profiling of thousands of tumor samples, which may be used to decipher cancer …

From development to cancer-an ever-increasing role of AGR2

D Jach, Y Cheng, F Prica, L Dumartin… - American journal of …, 2021 - pmc.ncbi.nlm.nih.gov
Anterior gradient 2, AGR2, is a small, 20 kDa protein that plays a vital role in oxidative
protein folding in the endoplasmic reticulum. AGR2 is involved in several signal transduction …

[HTML][HTML] Prostate cancer research: tools, cell types, and molecular targets

AY Liu - Frontiers in Oncology, 2024 - frontiersin.org
Multiple cancer cell types are found in prostate tumors. They are either luminal-like
adenocarcinoma or less luminal-like and more stem-like non-adenocarcinoma and small …