For breast and ovarian cancer risk assessment in the isolated populations of the Northern
Isles of Orkney and Shetland (in Scotland, UK) and their diasporas, quantifying genetically …

In the era of precision medicine, genetic test results have become increasingly relevant in
the care of patients with Parkinson's disease (PD) and their families. While large PD …

Large-scale population cohort studies that collect genomic information are tasked with
returning an assessment of genetic risk for hereditary cancers to participants. While several …

Abstract Purpose Participants in the 100,000 Genomes Project, a clinical/research initiative
delivered through the UK National Health Service, were offered screening for “additional …

Background and Objectives In the era of precision medicine, genetic test results have
become increasingly relevant in the care of patients with Parkinson disease (PD). While …

Pathogenic variants in BRCA1 and BRCA2 confer a high lifetime risk of breast, ovarian and,
for BRCA2, male breast and prostate cancer [1–3]. Genetic testing for disease-associated …

Background Inborn errors of immunity (IEIs) comprise more than 500 different rare
congenital disorders of the immune system and are characterized by susceptibility to …

Introduction Returning research-based genetic results (gRoR) to participants in nephrology
research can improve care; however, the practice raises implementational questions and no …

For breast and ovarian cancer risk assessment in the isolated populations of the Northern
Isles of Orkney and Shetland (in Scotland, UK) and their diasporas, quantifying genetically …

The benefits of returning clinically actionable genetic results to participants in research
cohorts are accruing, yet such a genome-first approach is challenging. Here, we describe …