Towards a deeper understanding of the vaginal microbiota

M France, M Alizadeh, S Brown, B Ma, J Ravel - Nature microbiology, 2022 - nature.com
The human vaginal microbiota is a critical determinant of vaginal health. These communities
live in close association with the vaginal epithelium and rely on host tissues for resources …

Vaginal microbiome: normalcy vs dysbiosis

VS Saraf, SA Sheikh, A Ahmad, PM Gillevet… - Archives of …, 2021 - Springer
It has been long understood that the vaginal microflora is crucial in maintaining a normal
physiological environment for the host and its involvement is deemed indispensable for …

The vaginal microbiome and preterm birth

JM Fettweis, MG Serrano, JP Brooks, DJ Edwards… - Nature medicine, 2019 - nature.com
The incidence of preterm birth exceeds 10% worldwide. There are significant disparities in
the frequency of preterm birth among populations within countries, and women of African …

The vaginal microbiome and the risk of preterm birth: a systematic review and network meta-analysis

U Gudnadottir, JW Debelius, J Du, LW Hugerth… - Scientific reports, 2022 - nature.com
Preterm birth is a major cause of neonatal morbidity and mortality worldwide. Increasing
evidence links the vaginal microbiome to the risk of spontaneous preterm labour that leads …

Interferons and proinflammatory cytokines in pregnancy and fetal development

LJ Yockey, A Iwasaki - Immunity, 2018 - cell.com
Successful pregnancy requires carefully-coordinated communications between the mother
and fetus. Immune cells and cytokine signaling pathways participate as mediators of these …

[HTML][HTML] The central nervous system and the gut microbiome

G Sharon, TR Sampson, DH Geschwind… - Cell, 2016 - cell.com
Neurodevelopment is a complex process governed by both intrinsic and extrinsic signals.
While historically studied by researching the brain, inputs from the periphery impact many …

Cervicovaginal microbiota and local immune response modulate the risk of spontaneous preterm delivery

MA Elovitz, P Gajer, V Riis, AG Brown… - Nature …, 2019 - nature.com
Failure to predict and understand the causes of preterm birth, the leading cause of neonatal
morbidity and mortality, have limited effective interventions and therapeutics. From a cohort …

Evidence that the endometrial microbiota has an effect on implantation success or failure

I Moreno, FM Codoñer, F Vilella, D Valbuena… - American journal of …, 2016 - Elsevier
Background Bacterial cells in the human body account for 1–3% of total body weight and are
at least equal in number to human cells. Recent research has focused on understanding …

Risk factors for spontaneous preterm delivery

T Cobo, M Kacerovsky… - International Journal of …, 2020 - Wiley Online Library
Background There is a substantial variation in rates of preterm delivery between different
parts of the world. The understanding of these variations, as well as the biological …

Replication and refinement of a vaginal microbial signature of preterm birth in two racially distinct cohorts of US women

BJ Callahan, DB DiGiulio, DSA Goltsman… - Proceedings of the …, 2017 - pnas.org
Preterm birth (PTB) is the leading cause of neonatal morbidity and mortality. Previous
studies have suggested that the maternal vaginal microbiota contributes to the …