Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities

A Choudhury, ST Magill, CD Eaton, BC Prager… - Nature …, 2022 - nature.com
Meningiomas are the most common primary intracranial tumors. There are no effective
medical therapies for meningioma patients, and new treatments have been encumbered by …

cIMPACT-NOW Update 8: Clarifications on molecular risk parameters and recommendations for WHO grading of meningiomas

F Sahm, KD Aldape, PK Brastianos, DJ Brat… - Neuro …, 2024 - academic.oup.com
Meningiomas are the most frequent primary intracranial tumors. Hence, they constitute a
major share of diagnostic specimens in neuropathology practice. The 2021 WHO …

Radiotherapy for meningiomas

WC Chen, HK Perlow, A Choudhury, MP Nguyen… - Journal of neuro …, 2022 - Springer
Meningiomas are the most common primary central nervous system neoplasm. Despite
promising recent progress in elucidating the genomic landscape and underlying biology of …

Hypermitotic meningiomas harbor DNA methylation subgroups with distinct biological and clinical features

A Choudhury, WC Chen, CHG Lucas… - Neuro …, 2023 - academic.oup.com
Background Meningiomas, the most common primary intracranial tumors, can be separated
into 3 DNA methylation groups with distinct biological drivers, clinical outcomes, and …

Radiotherapy and radiosurgery for meningiomas

WC Chen, CHG Lucas, ST Magill… - Neuro-Oncology …, 2023 - academic.oup.com
Meningiomas comprise a histologically and clinically diverse set of tumors arising from the
meningothelial lining of the central nervous system. In the past decade, remarkable progress …

Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses

WC Chen, A Choudhury, MW Youngblood… - Nature medicine, 2023 - nature.com
Surgery is the mainstay of treatment for meningioma, the most common primary intracranial
tumor, but improvements in meningioma risk stratification are needed and indications for …

Molecular classification and grading of meningioma

MLP Nasrallah, KD Aldape - Journal of Neuro-Oncology, 2023 - Springer
Purpose Meningiomas are the most common primary intracranial tumor in older adults
(Ostrom et al. in Neuro Oncol 21 (Suppl 5): v1–v100, 2019). Treatment is largely driven by, in …

EANO guideline on molecular testing of meningiomas for targeted therapy selection

F Sahm, L Bertero, S Brandner, D Capper… - Neuro …, 2024 - academic.oup.com
Meningiomas are the most common primary intracranial tumors of adults. For meningiomas
that progress or recur despite surgical resection and radiotherapy, additional treatment …

RNA splicing as a biomarker and phenotypic driver of meningioma DNA-methylation groups

NK Leclair, A Choudury, WC Chen, ST Magill… - Neuro …, 2024 - academic.oup.com
Background Advances in our understanding of the molecular biology of meningiomas have
led to significant gains in the ability to predict patient prognosis and tumor recurrence and to …

Gene expression analysis during progression of malignant meningioma compared to benign meningioma

AD Maier, A Meddis, C Mirian, J Haslund-Vinding… - Journal of …, 2022 - thejns.org
OBJECTIVE Meningioma is the most common primary intracranial neoplasm. Only 1%–3%
of meningiomas are malignant according to the 2016 WHO criteria (WHO grade III). High …