Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities
Meningiomas are the most common primary intracranial tumors. There are no effective
medical therapies for meningioma patients, and new treatments have been encumbered by …
medical therapies for meningioma patients, and new treatments have been encumbered by …
cIMPACT-NOW Update 8: Clarifications on molecular risk parameters and recommendations for WHO grading of meningiomas
Meningiomas are the most frequent primary intracranial tumors. Hence, they constitute a
major share of diagnostic specimens in neuropathology practice. The 2021 WHO …
major share of diagnostic specimens in neuropathology practice. The 2021 WHO …
Radiotherapy for meningiomas
Meningiomas are the most common primary central nervous system neoplasm. Despite
promising recent progress in elucidating the genomic landscape and underlying biology of …
promising recent progress in elucidating the genomic landscape and underlying biology of …
Hypermitotic meningiomas harbor DNA methylation subgroups with distinct biological and clinical features
Background Meningiomas, the most common primary intracranial tumors, can be separated
into 3 DNA methylation groups with distinct biological drivers, clinical outcomes, and …
into 3 DNA methylation groups with distinct biological drivers, clinical outcomes, and …
Radiotherapy and radiosurgery for meningiomas
Meningiomas comprise a histologically and clinically diverse set of tumors arising from the
meningothelial lining of the central nervous system. In the past decade, remarkable progress …
meningothelial lining of the central nervous system. In the past decade, remarkable progress …
Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses
Surgery is the mainstay of treatment for meningioma, the most common primary intracranial
tumor, but improvements in meningioma risk stratification are needed and indications for …
tumor, but improvements in meningioma risk stratification are needed and indications for …
Molecular classification and grading of meningioma
Purpose Meningiomas are the most common primary intracranial tumor in older adults
(Ostrom et al. in Neuro Oncol 21 (Suppl 5): v1–v100, 2019). Treatment is largely driven by, in …
(Ostrom et al. in Neuro Oncol 21 (Suppl 5): v1–v100, 2019). Treatment is largely driven by, in …
EANO guideline on molecular testing of meningiomas for targeted therapy selection
Meningiomas are the most common primary intracranial tumors of adults. For meningiomas
that progress or recur despite surgical resection and radiotherapy, additional treatment …
that progress or recur despite surgical resection and radiotherapy, additional treatment …
RNA splicing as a biomarker and phenotypic driver of meningioma DNA-methylation groups
Background Advances in our understanding of the molecular biology of meningiomas have
led to significant gains in the ability to predict patient prognosis and tumor recurrence and to …
led to significant gains in the ability to predict patient prognosis and tumor recurrence and to …
Gene expression analysis during progression of malignant meningioma compared to benign meningioma
OBJECTIVE Meningioma is the most common primary intracranial neoplasm. Only 1%–3%
of meningiomas are malignant according to the 2016 WHO criteria (WHO grade III). High …
of meningiomas are malignant according to the 2016 WHO criteria (WHO grade III). High …