Neutrophils are the first responders to infection and inflammation and are thus a critical
component of innate immune defense. Understanding the behavior of neutrophils as they …

Neutrophils are major effectors and regulators of the immune system. They play critical roles
not only in the eradication of pathogens but also in cancer initiation and progression …

Clear cell renal carcinoma (ccRCC) is a heterogeneous disease with a variable post-
surgical course. To assemble a comprehensive ccRCC tumor microenvironment (TME) …

Renal cell carcinoma (RCC) is the most common type of kidney cancer and comprises
several subtypes with unique characteristics. The most common subtype (~ 70% of cases) is …

We describe results from IMmotion150, a randomized phase 2 study of atezolizumab (anti-
PD-L1) alone or combined with bevacizumab (anti-VEGF) versus sunitinib in 305 patients …

Although elevated plasma interleukin-8 (pIL-8) has been associated with poor outcome to
immune checkpoint blockade, this has not been comprehensively evaluated in large …

Mutational inactivation of VHL is the earliest genetic event in the majority of clear cell renal
cell carcinomas (ccRCC), leading to accumulation of the HIF-1α and HIF-2α transcription …

Distant metastasis is a primary cause of mortality and contributes to poor surgical outcomes
in cancer patients. Before the development of organ-specific metastasis, the formation of a …

Chemokines, which are basic proteins that exert their effects via G protein-coupled receptors
and a subset of the cytokine family, are mediators deeply involved in leukocyte migration …

The chemokine receptor CXCR2 and its ligands are implicated in the progression of tumours
and various inflammatory diseases. Activation of the CXCLs/CXCR2 axis activates multiple …