Epidemiology, pathophysiology and contemporary management of cardiogenic shock–a position statement from the Heart Failure Association of the European Society …
O Chioncel, J Parissis, A Mebazaa… - European journal of …, 2020 - Wiley Online Library
Cardiogenic shock (CS) is a complex multifactorial clinical syndrome with extremely high
mortality, develo** as a continuum, and progressing from the initial insult (underlying …
mortality, develo** as a continuum, and progressing from the initial insult (underlying …
Targeting the sarcomere in inherited cardiomyopathies
Variants in> 12 genes encoding sarcomeric proteins can cause various cardiomyopathies.
The two most common are hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy …
The two most common are hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy …
Levosimendan efficacy and safety: 20 years of SIMDAX in clinical use
Levosimendan was first approved for clinical use in 2000, when authorization was granted
by Swedish regulatory authorities for the hemodynamic stabilization of patients with acutely …
by Swedish regulatory authorities for the hemodynamic stabilization of patients with acutely …
Treatments targeting inotropy: a position paper of the Committees on Translational Research and Acute Heart Failure of the Heart Failure Association of the European …
Acute heart failure (HF) and in particular, cardiogenic shock are associated with high
morbidity and mortality. A therapeutic dilemma is that the use of positive inotropic agents …
morbidity and mortality. A therapeutic dilemma is that the use of positive inotropic agents …
Levosimendan: molecular mechanisms and clinical implications: consensus of experts on the mechanisms of action of levosimendan
The molecular background of the Ca2+-sensitizing effect of levosimendan relates to its
specific interaction with the Ca2+-sensor troponin C molecule in the cardiac myofilaments …
specific interaction with the Ca2+-sensor troponin C molecule in the cardiac myofilaments …
Targeting the sarcomere to correct muscle function
Various human diseases can disrupt the balance between muscle contraction and
relaxation. Sarcomeric modulators can be used to readjust this balance either indirectly by …
relaxation. Sarcomeric modulators can be used to readjust this balance either indirectly by …
Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs
In striated muscle, the protein troponin complex turns contraction on and off in a calcium-
dependent manner. The calcium-sensing component of the complex is troponin C, which is …
dependent manner. The calcium-sensing component of the complex is troponin C, which is …
Pharmacology of levosimendan: inotropic, vasodilatory and cardioprotective effects
A Pathak, M Lebrin, A Vaccaro… - Journal of clinical …, 2013 - Wiley Online Library
What is known and objective Positive inotropic agents are frequently used in acute
decompensated heart failure (ADHF) due to left ventricular systolic dysfunction. These …
decompensated heart failure (ADHF) due to left ventricular systolic dysfunction. These …
[PDF][PDF] Levosimendan, a new inotropic and vasodilator agent
WG Toller, C Stranz, DC Warltier - Anesthesiology, 2006 - jvsmedicscorner.com
This article has been selected for the Anesthesiology CME Program. After reading the
article, go to http://www. asahq. org/journal-cme to take the test and apply for Category 1 …
article, go to http://www. asahq. org/journal-cme to take the test and apply for Category 1 …
Evidence-based use of levosimendan in different clinical settings
Levosimendan is a new calcium sensitizer and K-ATP channel opener. Compared with other
inodilators, it improves myocardial contractility without increasing oxygen requirements and …
inodilators, it improves myocardial contractility without increasing oxygen requirements and …