Bacterial siderophores: diversity, uptake pathways and applications

IJ Schalk - Nature Reviews Microbiology, 2024 - nature.com
Iron is an essential nutrient for the growth, survival and virulence of almost all bacteria. To
access iron, many bacteria produce siderophores, molecules with a high affinity for iron …

[HTML][HTML] Oxidative Stress Response in Pseudomonas aeruginosa

WS da Cruz Nizer, V Inkovskiy, Z Versey, N Strempel… - Pathogens, 2021 - mdpi.com
Pseudomonas aeruginosa is a Gram-negative environmental and human opportunistic
pathogen highly adapted to many different environmental conditions. It can cause a wide …

Pseudomonas aeruginosa and its multiple strategies to access iron

IJ Schalk, Q Perraud - Environmental Microbiology, 2023 - Wiley Online Library
Pseudomonas aeruginosa is a ubiquitous bacterium found in many natural and man‐made
environments. It is also a pathogen for plants, animals, and humans. As for almost all living …

[HTML][HTML] Bacterial iron detoxification at the molecular level

JM Bradley, DA Svistunenko, MT Wilson… - Journal of Biological …, 2020 - Elsevier
Iron is an essential micronutrient, and, in the case of bacteria, its availability is commonly a
growth-limiting factor. However, correct functioning of cells requires that the labile pool of …

Bacterial zinc uptake regulator proteins and their regulons

A Mikhaylina, AZ Ksibe, DJ Scanlan… - Biochemical Society …, 2018 - portlandpress.com
All organisms must regulate the cellular uptake, efflux, and intracellular trafficking of
essential elements, including d-block metal ions. In bacteria, such regulation is achieved by …

Meddling with metal sensors: Fur-family proteins as signaling hubs

CH Steingard, JD Helmann - Journal of Bacteriology, 2023 - journals.asm.org
The ferric uptake regulator (Fur) protein is the founding member of the FUR superfamily of
metalloregulatory proteins that control metal homeostasis in bacteria. FUR proteins regulate …

[HTML][HTML] Fur-like proteins: beyond the ferric uptake regulator (Fur) paralog

E Sevilla, MT Bes, ML Peleato, MF Fillat - Archives of biochemistry and …, 2021 - Elsevier
Proteins belonging to the FUR (ferric uptake regulator) family are the cornerstone of
metalloregulation in most prokaryotes. Although numerous reviews have been devoted to …

A single sensor controls large variations in zinc quotas in a marine cyanobacterium

A Mikhaylina, AZ Ksibe, RC Wilkinson, D Smith… - Nature Chemical …, 2022 - nature.com
Marine cyanobacteria are critical players in global nutrient cycles that crucially depend on
trace metals in metalloenzymes, including zinc for CO2 fixation and phosphorus acquisition …

[HTML][HTML] Allosteric control of metal-responsive transcriptional regulators in bacteria

KA Baksh, DB Zamble - Journal of Biological Chemistry, 2020 - Elsevier
Many transition metals are essential trace nutrients for living organisms, but they are also
cytotoxic in high concentrations. Bacteria maintain the delicate balance between metal …

The pathogen Pseudomonas aeruginosa optimizes the production of the siderophore pyochelin upon environmental challenges

O Cunrath, G Graulier, A Carballido-Lopez… - Metallomics, 2020 - academic.oup.com
Siderophores are iron chelators produced by bacteria to access iron, an essential nutrient.
The pathogen Pseudomonas aeruginosa produces two siderophores, pyoverdine and …