Biological ion channels are nanoscale transmembrane pores. When water and ions are
enclosed within the narrow confines of a sub-nanometer hydrophobic pore, they exhibit …

The conversion of force into an electrical cellular signal is mediated by the opening of
different types of mechanosensitive ion channels (MSCs), including TREK/TRAAK K 2P …

Activation of mechanosensitive ion channels by physical force underlies many physiological
processes including the sensation of touch, hearing and pain,,,,. TRAAK (also known as …

TREK-2 (KCNK10/K2P10), a two-pore domain potassium (K2P) channel, is gated by
multiple stimuli such as stretch, fatty acids, and pH and by several drugs. However, the …

Monday, February 19, 2018 303a neuronal excitability, respond to lipids, temperature and
mechanical stretch, and influence pain, temperature perception and anaesthetic responses …

Potassium channels participate in many biological functions, from ion homeostasis to
generation and modulation of the electrical membrane potential. They are involved in a …

Optogenetics is increasingly used to map brain activation using techniques that rely on
functional hyperaemia, such as opto-fMRI. Here we test whether light stimulation protocols …

Tandem pore domain (K2P) potassium channels modulate resting membrane potentials and
shape cellular excitability. For the mechanosensitive subfamily of K2Ps, the composition of …

Mechanical and thermal activation of ion channels is central to touch, thermosensation, and
pain. The TRAAK/TREK K 2P potassium channel subfamily produces background currents …

K2P potassium channels regulate cellular excitability using their selectivity filter (C-type)
gate. C-type gating mechanisms, best characterized in homotetrameric potassium channels …