Association of glycemic indices (hyperglycemia, glucose variability, and hypoglycemia) with oxidative stress and diabetic complications

E Papachristoforou, V Lambadiari… - Journal of diabetes …, 2020 - Wiley Online Library
Oxidative stress (OS) is defined as a disturbance in the prooxidant‐antioxidant balance of
the cell, in favor of the former, which results in the antioxidant capacity of the cell to be …

Complications of diabetes and metrics of glycemic management derived from continuous glucose monitoring

M Yapanis, S James, ME Craig… - The Journal of …, 2022 - academic.oup.com
Context Although glycated hemoglobin A1c is currently the best parameter used clinically to
assess risk for the development of diabetes complications, it does not provide insight into …

Association of time in range, as assessed by continuous glucose monitoring, with diabetic retinopathy in type 2 diabetes

J Lu, X Ma, J Zhou, L Zhang, Y Mo, L Ying, W Lu… - Diabetes …, 2018 - Am Diabetes Assoc
OBJECTIVE Continuous glucose monitoring (CGM) has provided new measures of glycemic
control that link to diabetes complications. This study investigated the association between …

Glycemic variability in the development of cardiovascular complications in diabetes

A Nusca, D Tuccinardi, M Albano… - Diabetes/metabolism …, 2018 - Wiley Online Library
Diabetes mellitus represents a major risk factor for the development of coronary artery
disease and other vascular complications. Glycated haemoglobin, fructosamine, and fasting …

Innate immune memory in cardiometabolic disease

H Bahrar, S Bekkering, R Stienstra… - Cardiovascular …, 2023 - academic.oup.com
Low-grade systemic inflammation is a key pathophysiological component of atherosclerotic
cardiovascular disease (CVD), and long-term activation of myeloid cells is thought to be …

Assessment of the association between glycemic variability and diabetes-related complications in type 1 and type 2 diabetes

J Smith-Palmer, M Brändle, R Trevisan… - Diabetes research and …, 2014 - Elsevier
Chronic hyperglycemia is the main risk factor for the development of diabetes-related
complications in both type 1 and type 2 diabetes, but it is thought that frequent or large …

HbA1c variability and diabetic peripheral neuropathy in type 2 diabetic patients

J Su, L Zhao, X Zhang, H Cai, H Huang, F Xu… - Cardiovascular …, 2018 - Springer
Background Diabetic complications may be associated with impaired time-dependent
glycemic control. Therefore, long-term glycemic variability, assessed by variations in …

Relationship between fluctuations in glucose levels measured by continuous glucose monitoring and vascular endothelial dysfunction in type 2 diabetes mellitus

K Torimoto, Y Okada, H Mori, Y Tanaka - Cardiovascular diabetology, 2013 - Springer
Background Fluctuations in blood glucose level cause endothelial dysfunction and play a
critical role in onset and/or progression of atherosclerosis. We hypothesized that fluctuation …

Time in range, as a novel metric of glycemic control, is reversely associated with presence of diabetic cardiovascular autonomic neuropathy independent of HbA1c in …

Q Guo, P Zang, S Xu, W Song, Z Zhang… - Journal of diabetes …, 2020 - Wiley Online Library
Objective. The objective of this study is to investigate the relationship between time in range
(TIR), a new metric of continuous glucose monitoring (CGM) and cardiovascular autonomic …

Glycemic variability is a powerful independent predictive factor of midterm major adverse cardiac events in patients with diabetes with acute coronary syndrome

E Gerbaud, R Darier, M Montaudon… - Diabetes …, 2019 - Am Diabetes Assoc
OBJECTIVE Acute glucose fluctuations are associated with hypoglycemia and are emerging
risk factors for cardiovascular outcomes. However, the relationship between glycemic …