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Shadow enhancers: Frequently asked questions about distributed cis‐regulatory information and enhancer redundancy
This paper, in the form of a frequently asked questions page (FAQ), addresses outstanding
questions about “shadow enhancers”, quasi‐redundant cis‐regulatory elements, and their …
questions about “shadow enhancers”, quasi‐redundant cis‐regulatory elements, and their …
Cis-regulatory landscapes in the evolution and development of the mammalian skull
Extensive morphological variation found in mammals reflects the wide spectrum of their
ecological adaptations. The highest morphological diversity is present in the craniofacial …
ecological adaptations. The highest morphological diversity is present in the craniofacial …
Evolution of transcriptional enhancers and animal diversity
Deciphering the genetic bases that drive animal diversity is one of the major challenges of
modern biology. Although four decades ago it was proposed that animal evolution was …
modern biology. Although four decades ago it was proposed that animal evolution was …
Targeted transgene integration overcomes variability of position effects in zebrafish
Zebrafish transgenesis is increasingly popular owing to the optical transparency and
external development of embryos, which provide a scalable vertebrate model for in vivo …
external development of embryos, which provide a scalable vertebrate model for in vivo …
Regulatory interactions specifying Kolmer-Agduhr interneurons
In the zebrafish spinal cord, two classes of neurons develop from the lateral floor plate:
Kolmer-Agduhr′(KA′) and V3 interneurons. We show here that the differentiation of the …
Kolmer-Agduhr′(KA′) and V3 interneurons. We show here that the differentiation of the …
Cis-regulatory evolution of the recently expanded Ly49 gene family
Comparative genomics has revealed the rapid expansion of multiple gene families involved
in immunity. Members within each gene family often evolved distinct roles in immunity …
in immunity. Members within each gene family often evolved distinct roles in immunity …
Evolutionary Genomics and Adaptive Evolution of the Hedgehog Gene Family (Shh, Ihh and Dhh) in Vertebrates
The Hedgehog (Hh) gene family codes for a class of secreted proteins composed of two
active domains that act as signalling molecules during embryo development, namely for the …
active domains that act as signalling molecules during embryo development, namely for the …
[HTML][HTML] The words of the regulatory code are arranged in a variable manner in highly conserved enhancers
The cis-regulatory regions of many developmental regulators and transcription factors are
believed to be highly conserved in the genomes of vertebrate species, suggesting specific …
believed to be highly conserved in the genomes of vertebrate species, suggesting specific …
Analysis of the transcriptome of the Indonesian coelacanth Latimeria menadoensis
Background Latimeria menadoensis is a coelacanth species first identified in 1997 in
Indonesia, at 10,000 Km of distance from its African congener. To date, only six specimens …
Indonesia, at 10,000 Km of distance from its African congener. To date, only six specimens …
[HTML][HTML] Cis-regulation and chromosomal rearrangement of the fgf8 locus after the teleost/tetrapod split
The complex expression pattern of fibroblast growth factor 8 (Fgf8) and the cellular
responses dependent on concentration of its mRNA in vertebrates suggest that Fgf8 should …
responses dependent on concentration of its mRNA in vertebrates suggest that Fgf8 should …