Tuberculosis drug discovery: challenges and new horizons
Over the past 2000 years, tuberculosis (TB) has claimed more lives than any other infectious
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …
Coumarin–benzimidazole hybrids: A review of developments in medicinal chemistry
Coumarin and benzimidazole are privileged structures in medicinal chemistry and are
widely used in drug discovery and development due to their vast biological properties. The …
widely used in drug discovery and development due to their vast biological properties. The …
Aggregation-induced emission nanoparticles for single near-infrared light-triggered photodynamic and photothermal antibacterial therapy
W Wang, F Wu, Q Zhang, N Zhou, M Zhang, T Zheng… - ACS …, 2022 - ACS Publications
Phototheranostics is a potential area for precision medicine, which has received increasing
attention for antibacterial applications. Integrating all phototheranostic modalities in a single …
attention for antibacterial applications. Integrating all phototheranostic modalities in a single …
Recent developments of imidazo [1, 2-a] pyridine analogues as antituberculosis agents
Over the past 2000 years, tuberculosis (TB) has killed more people than any other infectious
disease. In 2021, TB claimed 1.6 million lives worldwide, making it the second leading …
disease. In 2021, TB claimed 1.6 million lives worldwide, making it the second leading …
The struggle to end a millennia-long pandemic: novel candidate and repurposed drugs for the treatment of tuberculosis
BD Edwards, SK Field - Drugs, 2022 - Springer
This article provides an encompassing review of the current pipeline of putative and
developed treatments for tuberculosis, including multidrug-resistant strains. The review has …
developed treatments for tuberculosis, including multidrug-resistant strains. The review has …
Spiropyrimidinetrione DNA gyrase inhibitors with potent and selective antituberculosis activity
New antibiotics with either a novel mode of action or novel mode of inhibition are urgently
needed to overcome the threat of drug-resistant tuberculosis (TB). The present study profiles …
needed to overcome the threat of drug-resistant tuberculosis (TB). The present study profiles …
Molecular docking, molecular dynamics simulations and binding free energy studies of interactions between Mycobacterium tuberculosis Pks13, PknG and bioactive …
Mycobacterial pathogens present a significant challenge to disease control efforts globally
due to their inherent resistance to multiple antibiotics. The rise of drug-resistant strains of …
due to their inherent resistance to multiple antibiotics. The rise of drug-resistant strains of …
Recent advancements and developments in search of anti-tuberculosis agents: a quinquennial update and future directions
Tuberculosis (TB) has been considered as the highly chronic, contagious and infectious
disorder caused by Mycobacterium tuberculosis (Mtb). Every year more than 10 million …
disorder caused by Mycobacterium tuberculosis (Mtb). Every year more than 10 million …
Polydopamine‐Engineered Theranostic Nanoscouts Enabling Intracellular HSP90 mRNAs Fluorescence Detection for Imaging‐Guided Chemo–Photothermal …
G Yang, M Li, T Song, X Chen, H Zhang… - Advanced …, 2022 - Wiley Online Library
The combination of photothermal therapy (PTT) and chemotherapy is considered a
promising tumor treatment modality, nevertheless, cellular resistance induced by heat shock …
promising tumor treatment modality, nevertheless, cellular resistance induced by heat shock …
Hepatocyte ferroptosis contributes to anti-tuberculosis drug-induced liver injury: Involvement of the HIF-1α/SLC7A11/GPx4 axis
Y Liu, W Chen, Y Cen, X Zhao, Z Chen, Y Liang… - Chemico-biological …, 2023 - Elsevier
Anti-tuberculosis drug-induced liver injury (ATB-DILI) is a common serious adverse event
observed during the clinical treatment of tuberculosis. However, the molecular mechanisms …
observed during the clinical treatment of tuberculosis. However, the molecular mechanisms …