INTRODUCTION In recent years, the single-cell genomics field has made incredible
progress toward disentangling the cellular heterogeneity of human tissues. However, the …

Hepatocyte nuclear factor-1β (HNF-1β) is an essential transcription factor that regulates the
development and function of epithelia in the kidney, liver, pancreas, and genitourinary tract …

Kidney organoids made from pluripotent stem cells have the potential to revolutionize how
kidney development, disease, and injury are studied. Current protocols are technically …

Hepatocyte nuclear factor-1β (HNF-1β) is a DNA-binding transcription factor that is essential
for normal kidney development. Mutations of HNF1B in humans produce cystic kidney …

Ureteric bud (UB) is the embryonic kidney progenitor tissue that gives rise to the collecting
duct and lower urinary tract. UB-like structures generated from human pluripotent stem cells …

Transcription factor networks shape the gene expression programs responsible for normal
cell identity and pathogenic state. Using Core Regulatory Circuitry analysis (CRC), we …

Background Mutations in the transcription factor hepatocyte nuclear factor 1B (HNF1B) are
the most common inherited cause of renal malformations, yet also associated with renal …

Background Mutation of HNF1B, the gene encoding transcription factor HNF-1β, is one
cause of autosomal dominant tubulointerstitial kidney disease, a syndrome characterized by …

Mayer–Rokitansky–Küster–Hauser (MRKH) syndrome is a congenital condition
characterized by aplasia or hypoplasia of the uterus and vagina in women with a 46, XX …

Collagen XVIII (ColXVIII) is a component of the extracellular matrix implicated in
embryogenesis and control of tissue homoeostasis. We now provide evidence that ColXVIII …