Inflammatory processes underlie a broad spectrum of conditions that injure the heart muscle
and cause both structural and functional deficits. In this article, we address current …

This article provides the first extensive documentation of the dose response features of pre-
and postconditioning. Pre-and postconditioning studies with rigorous study designs, using …

The rise of antibiotic resistance and declining discovery of new antibiotics has created a
global health crisis. Of particular concern, no new antibiotic classes have been approved for …

Emerging evidence shows a broad spectrum of biological functions of tissue factor (TF). TF
classical role in initiating the extrinsic blood coagulation and its direct thrombotic action in …

During an ST-elevation myocardial infarction (STEMI), the myocardium undergoes a
prolonged period of ischaemia. Reperfusion therapy is essential to minimize cardiac injury …

Aims Atrial fibrillation (AF) produces a hypercoagulable state. Stimulation of protease-
activated receptors by coagulation factors provokes pro-fibrotic, pro-hypertrophic, and pro …

Bacterial infections are characterized by their rapid and widespread proliferation, leading to
significant morbidity. Despite the availability of a variety of antimicrobial drugs, the …

Coagulation is a host defense system that limits the spread of pathogens. Coagulation
proteases, such as thrombin, also activate cells by cleaving PARs. In this study, we analyzed …

Platelets are important actors of cardiovascular diseases (CVD). Current antiplatelet drugs
that inhibit platelet aggregation have been shown to be effective in CVD treatment. However …

The attachment of circulating tumor cells to the blood vessels of distant organs is an
important step in metastasis. We show here that experimental lung metastasis by two cell …