Radiomics: a primer on high-throughput image phenoty**

KJ Lafata, Y Wang, B Konkel, FF Yin, MR Bashir - Abdominal Radiology, 2022 - Springer
Radiomics is a high-throughput approach to image phenoty**. It uses computer
algorithms to extract and analyze a large number of quantitative features from radiological …

[HTML][HTML] Advances in constraint-based modelling of microbial communities

A Heinken, A Basile, I Thiele - Current Opinion in Systems Biology, 2021 - Elsevier
Microbial communities are near universally present in nature. A wealth of meta-omics data
has been gathered from numerous ecosystems, such as the human gut, ocean or soil …

Rationale and design of the kidney precision medicine project

IH de Boer, CE Alpers, EU Azeloglu, UGJ Balis… - Kidney international, 2021 - Elsevier
Chronic kidney disease (CKD) and acute kidney injury (AKI) are common, heterogeneous,
and morbid diseases. Mechanistic characterization of CKD and AKI in patients may facilitate …

Decoding clinical biomarker space of COVID-19: Exploring matrix factorization-based feature selection methods

F Saberi-Movahed, M Mohammadifard… - Computers in biology …, 2022 - Elsevier
One of the most critical challenges in managing complex diseases like COVID-19 is to
establish an intelligent triage system that can optimize the clinical decision-making at the …

Physical bioenergetics: Energy fluxes, budgets, and constraints in cells

X Yang, M Heinemann, J Howard… - Proceedings of the …, 2021 - National Acad Sciences
Cells are the basic units of all living matter which harness the flow of energy to drive the
processes of life. While the biochemical networks involved in energy transduction are well …

A systematic review exploring the association between the human gut microbiota and brain connectivity in health and disease

D Mulder, E Aarts, A Arias Vasquez… - Molecular …, 2023 - nature.com
A body of pre-clinical evidence shows how the gut microbiota influence brain functioning,
including brain connectivity. Linking measures of brain connectivity to the gut microbiota can …

Metabolic signature of hepatic fibrosis: from individual pathways to systems biology

ML Chang, SS Yang - Cells, 2019 - mdpi.com
Hepatic fibrosis is a major cause of morbidity and mortality worldwide, as it ultimately leads
to cirrhosis, which is estimated to affect up to 2% of the global population. Hepatic fibrosis is …

Results of the Seventh Scientific Workshop of ECCO: precision medicine in IBD—what, why, and how

C Fiocchi, G Dragoni, D Iliopoulos… - Journal of Crohn's …, 2021 - academic.oup.com
Many diseases that affect modern humans fall in the category of complex diseases, thus
called because they result from a combination of multiple aetiological and pathogenic …

Pathophysiology and therapeutics of thoracic aortic aneurysm in Marfan syndrome

K Asano, A Cantalupo, L Sedes, F Ramirez - Biomolecules, 2022 - mdpi.com
About 20% of individuals afflicted with thoracic aortic disease have single-gene mutations
that predispose the vessel to aneurysm formation and/or acute aortic dissection often without …

Fast track diagnostic tools for clinical management of sepsis: Paradigm shift from conventional to advanced methods

E Gupta, J Saxena, S Kumar, U Sharma, S Rastogi… - Diagnostics, 2023 - mdpi.com
Sepsis is one of the deadliest disorders in the new century due to specific limitations in early
and differential diagnosis. Moreover, antimicrobial resistance (AMR) is becoming the …