Most human genes have multiple sites at which RNA 3ʹ end cleavage and polyadenylation
can occur, enabling the expression of distinct transcript isoforms under different conditions …

Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …

Alternative polyadenylation (APA) is a pervasive mechanism in the regulation of most
human genes, and its implication in diseases including cancer is only beginning to be …

The 3′ end of most protein-coding genes and long non-coding RNAs is cleaved and
polyadenylated. Recent discoveries have revealed that a large proportion of these genes …

More than half of human genes use alternative cleavage and polyadenylation to generate
alternative 3′ untranslated region (3′ UTR) isoforms. Most efforts have focused on …

The global shortening of messenger RNAs through alternative polyadenylation (APA) that
occurs during enhanced cellular proliferation represents an important, yet poorly understood …

More than half of human genes use alternative cleavage and polyadenylation (ApA) to
generate mRNA transcripts that differ in the lengths of their 3′ untranslated regions (UTRs) …

Whole transcriptome analysis plays an essential role in deciphering genome structure and
function, identifying genetic networks underlying cellular, physiological, biochemical and …

The concept of early termination as an important means of transcriptional control has long
been established. Even so, its role in metazoan gene expression is underappreciated …

Cleavage and polyadenylation (C/P) of nascent transcripts is essential for maturation of the
3′ ends of most eukaryotic mRNAs. Over the past three decades, biochemical studies have …