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Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets
Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …
conversion from mechanical signals to biochemical signals regarding cell activities and …
Selected biomarkers of depression: what are the effects of cytokines and inflammation?
S Harsanyi, I Kupcova, L Danisovic, M Klein - International journal of …, 2022 - mdpi.com
Depression is one of the leading mental illnesses worldwide and lowers the quality of life of
many. According to WHO, about 5% of the worldwide population suffers from depression …
many. According to WHO, about 5% of the worldwide population suffers from depression …
[HTML][HTML] The therapeutic effects of saikosaponins on depression through the modulation of neuroplasticity: From molecular mechanisms to potential clinical …
S Chen, K Wang, H Wang, Y Gao, K Nie, X Jiang… - Pharmacological …, 2024 - Elsevier
Depression is a major global health issue that urgently requires innovative and precise
treatment options. In this context, saikosaponin has emerged as a promising candidate …
treatment options. In this context, saikosaponin has emerged as a promising candidate …
Menopause-associated depression: impact of oxidative stress and neuroinflammation on the central nervous system—a review
G Liang, ASF Kow, R Yusof, CL Tham, YC Ho, MT Lee - Biomedicines, 2024 - mdpi.com
Perimenopausal depression, occurring shortly before or after menopause, is characterized
by symptoms such as emotional depression, anxiety, and stress, often accompanied by …
by symptoms such as emotional depression, anxiety, and stress, often accompanied by …
Role of transforming growth factor-β in peripheral nerve regeneration
Z Ding, M Jiang, J Qian, D Gu, H Bai… - Neural Regeneration …, 2024 - journals.lww.com
Injuries caused by trauma and neurodegenerative diseases can damage the peripheral
nervous system and cause functional deficits. Unlike in the central nervous system …
nervous system and cause functional deficits. Unlike in the central nervous system …
Rare EIF4A2 variants are associated with a neurodevelopmental disorder characterized by intellectual disability, hypotonia, and epilepsy
MS Paul, AR Duncan, CA Genetti, H Pan… - The American Journal of …, 2023 - cell.com
Summary Eukaryotic initiation factor-4A2 (EIF4A2) is an ATP-dependent RNA helicase and
a member of the DEAD-box protein family that recognizes the 5ʹ cap structure of mRNAs …
a member of the DEAD-box protein family that recognizes the 5ʹ cap structure of mRNAs …
Extracellular proximal interaction profiling by cell surface–targeted TurboID reveals LDLR as a partner of liganded EGFR
R Al Mismar, P Samavarchi-Tehrani, B Seale… - Science …, 2024 - science.org
Plasma membrane proteins play pivotal roles in receiving and transducing signals from
other cells and from the environment and are vital for cellular functionality. Enzyme-based …
other cells and from the environment and are vital for cellular functionality. Enzyme-based …
Unraveling dysregulated cell signaling pathways, genetic and epigenetic mysteries of Parkinson's disease
Parkinson's disease (PD) is a prevalent and burdensome neurodegenerative disorder that
has been extensively researched to understand its complex etiology, diagnosis, and …
has been extensively researched to understand its complex etiology, diagnosis, and …
Crosstalk between the mTOR and Hippo pathways
D Honda, M Okumura, T Chihara - Development, Growth & …, 2023 - Wiley Online Library
Cell behavior changes in response to multiple stimuli, such as growth factors, nutrients, and
cell density. The mechanistic target of the rapamycin (mTOR) pathway is activated by growth …
cell density. The mechanistic target of the rapamycin (mTOR) pathway is activated by growth …
Molecular, circuit, and stress response characterization of ventral pallidum Npas1-neurons
Altered activity of the ventral pallidum (VP) underlies disrupted motivation in stress and drug
exposure. The VP is a very heterogeneous structure composed of many neuron types with …
exposure. The VP is a very heterogeneous structure composed of many neuron types with …