Pesticides at brain borders: Impact on the blood-brain barrier, neuroinflammation, and neurological risk trajectories
Pesticides are omnipresent, and they pose significant environmental and health risks.
Translational studies indicate that acute exposure to high pesticide levels is detrimental, and …
Translational studies indicate that acute exposure to high pesticide levels is detrimental, and …
[HTML][HTML] Persistent behavior deficits, neuroinflammation, and oxidative stress in a rat model of acute organophosphate intoxication
Current medical countermeasures for organophosphate (OP)-induced status epilepticus
(SE) are not effective in preventing long-term morbidity and there is an urgent need for …
(SE) are not effective in preventing long-term morbidity and there is an urgent need for …
Experimental and clinical biomarkers for progressive evaluation of neuropathology and therapeutic interventions for acute and chronic neurological disorders
This article describes commonly used experimental and clinical biomarkers of neuronal
injury and neurodegeneration for the evaluation of neuropathology and monitoring of …
injury and neurodegeneration for the evaluation of neuropathology and monitoring of …
Treating organophosphates poisoning: management challenges and potential solutions
M Alozi, M Rawas-Qalaji - Critical reviews in toxicology, 2020 - Taylor & Francis
Organophosphorus agents (OP) are widely used as pesticides due to their cost
effectiveness, yet they present a significant public health risk owing to their high toxicity …
effectiveness, yet they present a significant public health risk owing to their high toxicity …
[HTML][HTML] Midazolam-a diazepam replacement for the management of nerve agent-induced seizures.
L Gorecki, J Pejchal, C Torruellas, J Korabecny… - …, 2024 - Elsevier
A benzodiazepine, diazepam, has been the leading antidote for seizures caused by nerve
agents, the most toxic chemical weapons of mass destruction, since the 1960s. However, its …
agents, the most toxic chemical weapons of mass destruction, since the 1960s. However, its …
Saracatinib, a Src tyrosine kinase inhibitor, as a disease modifier in the rat DFP model: sex differences, Neurobehavior, gliosis, neurodegeneration, and nitro-oxidative …
M Gage, M Putra, L Wachter, K Dishman, M Gard… - Antioxidants, 2021 - mdpi.com
Diisopropylfluorophosphate (DFP), an organophosphate nerve agent (OPNA), exposure
causes status epilepticus (SE) and epileptogenesis. In this study, we tested the protective …
causes status epilepticus (SE) and epileptogenesis. In this study, we tested the protective …
Disease-modifying effects of a glial-targeted inducible nitric oxide synthase inhibitor (1400W) in mixed-sex cohorts of a rat soman (GD) model of epilepsy
Background Acute exposure to seizurogenic organophosphate (OP) nerve agents (OPNA)
such as diisopropylfluorophosphate (DFP) or soman (GD), at high concentrations, induce …
such as diisopropylfluorophosphate (DFP) or soman (GD), at high concentrations, induce …
[HTML][HTML] Inducible nitric oxide synthase inhibitor, 1400W, mitigates DFP-induced long-term neurotoxicity in the rat model
Chemical nerve agents (CNA) are increasingly becoming a threat to both civilians and
military personnel. CNA-induced acute effects on the nervous system have been known for …
military personnel. CNA-induced acute effects on the nervous system have been known for …
Comparative profile of refractory status epilepticus models following exposure of cholinergic agents pilocarpine, DFP, and soman
Status epilepticus (SE) is a medical emergency with continuous seizure activity that causes
profound neuronal damage, morbidity, or death. SE incidents can arise spontaneously but …
profound neuronal damage, morbidity, or death. SE incidents can arise spontaneously but …
[CITAS][C] Neurosteroids as novel anticonvulsants for refractory status epilepticus and medical countermeasures for nerve agents: A 15-year journey to bring …
DS Reddy - Journal of Pharmacology and Experimental …, 2024 - ASPET