Experimental models that faithfully mimic the developmental pathology of sporadic
Alzheimer's disease (sAD) in humans are important for testing the novel therapeutic …

A growing body of evidence implicates impairments in brain insulin signaling in early
sporadic Alzheimer disease (sAD) pathology. However, the most widely accepted …

Donepezil is the leading compound for the treatment of Alzheimer's disease (AD) in more
than 50 countries. As compared with other conventional acetylcholinesterase inhibitors …

Severe abnormalities in brain glucose/energy metabolism and insulin signaling have been
documented to take a pivotal role in early sporadic Alzheimer's disease (sAD) pathology …

Coenzyme Q10 (CoQ10), a peculiar lipophilic antioxidant, is an essential component of the
mitochondrial electron-transport chain. It is involved in the manufacturing of adenosine …

Alzheimer's disease (AD) is a neurodegenerative disorder that is remarkably characterized
by pathological hallmarks which include amyloid plaques, neurofibrillary tangles, neuronal …

Oxidative stress is involved in Alzheimer's disease (AD)-type neurodegeneration with
cognitive impairment (AD-TNDCI) as well as age related cognitive deficit. The present study …

The c-Jun N-terminal kinase (JNKs), also known as stress-activated protein kinase (SAPK),
is one such family of multifunctional-signaling molecules, activated in response to wide …

Previously we have demonstrated that a Rhodiola crenulata extract (RCE), containing a
potent antioxidant salidroside, promotes neurogenesis in the hippocampus of depressive …

In the present study, role of brain insulin receptors (IRs) in memory functions and its
correlation with acetylcholinesterase (AChE) activity and oxidative stress in different brain …