Pharmacological and biological effects of alpha-bisabolol: An updated review of the molecular mechanisms

E Ramazani, M Akaberi, SA Emami… - Life Sciences, 2022 - Elsevier
Abstract Alpha-bisabolol (α-bisabolol), an unsaturated monocyclic sesquiterpene alcohol, is
known as one of the “most-used herbal constituents” in the world. Various therapeutic and …

Health benefits, pharmacological effects, molecular mechanisms, and therapeutic potential of α-bisabolol

LB Eddin, NK Jha, SN Goyal, YO Agrawal… - Nutrients, 2022 - mdpi.com
α-Bisabolol is one of the important monocyclic sesquiterpenes, derived naturally from
essential oils of many edible and ornamental plants. It was first obtained from Matricaria …

Trypanocidal Mechanism of Action and in silico Studies of p-Coumaric Acid Derivatives

SP Lopes, YP Castillo, ML Monteiro… - International journal of …, 2019 - mdpi.com
Trypanosoma species are responsible for chronic and systemic infections in millions of
people around the world, compromising life quality, and family and government budgets …

Phytochemical composition, bioactive properties, and toxicological profile of Tetrapleura tetraptera

TG Anyamele, PN Onwuegbuchu, EA Ugbogu… - Bioorganic Chemistry, 2023 - Elsevier
The use of medicinal plants has gained renewed wide popularity in Africa, Asia, and most
parts of the world because of the decreasing efficacy of synthetic drugs. Thus, natural …

Chemistry and Bioactivity of Croton Essential Oils: Literature Survey and Croton hirtus from Vietnam

NA Luu-Dam, CVC Le, P Satyal, TMH Le, VH Bui… - Molecules, 2023 - mdpi.com
Using essential oils to control vectors, intermediate hosts, and disease-causing
microorganisms is a promising approach. The genus Croton in the family Euphorbiaceae is …

Chloride substitution on 2-hydroxy-3, 4, 6-trimethoxyphenylchalcones improves in vitro selectivity on Trypanosoma cruzi strain Y

EP Magalhães, NDB Gomes, TA De Freitas… - Chemico-Biological …, 2022 - Elsevier
Chagas disease is a disease that is emerging in North America and Europe countries.
Benznidazole is the main drug available, but it has high toxicity and low efficacy in the …

Antinociceptive activity of chemical components of essential oils that involves docking studies: a review

DB Assis, HC Aragão Neto, DV da Fonsêca… - Frontiers in …, 2020 - frontiersin.org
Introduction Pain is considered an unpleasant sensory and emotional experience, being
considered as one of the most important causes of human suffering. Computational …

Synthesis, vibrational analysis, thermal analysis, quantum-chemical calculation, molecular docking and dynamics, DMPK and evaluation of the antichagasic potential …

JVS Nunes, EM Marinho, CHA Roberto… - Journal of Molecular …, 2024 - Elsevier
Chagas disease affects 7 million people worldwide and is endemic in 20 Latin American
countries. It is estimated to cause about 14,000 deaths annually and more than 75 million …

Trypanocidal potential of synthetic p-aminochalcones: In silico and in vitro evaluation

NDB Gomes, EP Magalhães, LR Ribeiro… - Bioorganic …, 2023 - Elsevier
Chagas disease (CD) is a neglected tropical disease of worldwide health concern, caused
by the flagellate protozoan Trypanosoma cruzi (T. cruzi), endemic in Latin America and …

Acrylonitrile Derivatives against Trypanosoma cruzi: In Vitro Activity and Programmed Cell Death Study

CJ Bethencourt-Estrella, S Delgado-Hernández… - Pharmaceuticals, 2021 - mdpi.com
The neglected infection known as Chagas disease, caused by the protozoan parasite
Trypanosoma cruzi, results in more than 7000 deaths per year, with an increasing number of …