Background: Mild to moderate hypothermia (32–35 C) is the first treatment with proven
efficacy for postischemic neurological injury. In recent years important insights have been …

Myocardial reperfusion injury—triggered by an inevitable inflammatory response after
reperfusion—may undo a considerable part of the myocardial salvage achieved through …

Mild hypothermia reduces myocardial infarct size in small animals; however, the extent of
myocardial protection in large animals with greater thermal mass remains unknown. We …

OBJECTIVE: Extracorporeal circulation is considered the gold standard in the treatment of
hypothermic cardiocirculatory arrest; however, few centers use extracorporeal membrane …

Aim: The induction of mild hypothermia (MH; 33° C) has become the guideline therapy to
attenuate hypoxic brain injury after out‐of‐hospital cardiopulmonary resuscitation. While MH …

Background: From 1994, we have used therapeutic hypothermia in patients with severe
traumatic brain injury (Glasgow Coma Scale scores of 5 or less). In 2000, we altered the …

Hypothermia to mitigate ischemic brain tissue damage has a history of about six decades.
Both in clinical and experimental studies of hypothermia, two principal arbitrary patterns of …

Hypothermia, along with acidosis and coagulopathy, is part of the lethal triad that worsen the
prognosis of severe trauma patients. While accidental hypothermia is easy to identify by a …

Background Accidental hypothermia with arrested circulation remains a condition
associated with high mortality. In our institution, extracorporeal circulation (ECC) rewarming …

We have developed a multi-scale biophysical electromechanics model of the rat left ventricle
at room temperature. This model has been applied to investigate the relative roles of cellular …