Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle
health, and damage to mitochondria can lead to a series of pathophysiological changes …

Inflammation of the human lung is mediated in response to different stimuli (eg, physical,
radioactive, infective, pro-allergenic or toxic) such as cigarette smoke and environmental …

Metformin, the most prescribed antidiabetic medicine, has shown other benefits such as anti-
ageing and anticancer effects,,–. For clinical doses of metformin, AMP-activated protein …

Metabolic pathways integrate to support tissue homeostasis and to prompt changes in cell
phenotype. In particular, the heart consumes relatively large amounts of substrate not only to …

Adenosine monophosphate‐activated protein kinase (AMPK) is a cellular energy sensor
activated during energy stress that plays a key role in maintaining energy homeostasis. This …

Mitochondrial energy metabolism and oxidative stress play a crucial role in ameliorating
myocardial ischemia/reperfusion injury (MIRI). Tilianin has been reported to have a …

The activity of 5′-adenosine monophosphate-activated protein kinase (AMPK) is inversely
correlated with the cellular availability of glucose. When glucose levels are low, the …

Background: Right ventricular (RV) function is the major determinant for both functional
capacity and survival in patients with pulmonary arterial hypertension (PAH). Despite the …

Recent clinical trials of the hypoglycaemic sodium-glucose co-transporter-2 (SGLT2)
inhibitors, which inhibit renal glucose reabsorption, have reported beneficial cardiovascular …

Abstract β-Hydroxybutyrate (βOHB), a ketone body, is oxidised as a brain fuel. Although its
contribution to energy metabolism in the healthy brain is minimal, it is an interesting …