Strategies to access biosynthetic novelty in bacterial genomes for drug discovery
F Hemmerling, J Piel - Nature Reviews Drug Discovery, 2022 - nature.com
Bacteria provide a rich source of natural products with potential therapeutic applications,
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …
Bioactive metabolites from terrestrial and marine actinomycetes
C Ngamcharungchit, N Chaimusik, W Panbangred… - Molecules, 2023 - mdpi.com
Actinomycetes inhabit both terrestrial and marine ecosystems and are highly proficient in
producing a wide range of natural products with diverse biological functions, including …
producing a wide range of natural products with diverse biological functions, including …
Concepts and methods to access novel antibiotics from actinomycetes
Actinomycetes have been proven to be an excellent source of secondary metabolites for
more than half a century. Exhibiting various bioactivities, they provide valuable approved …
more than half a century. Exhibiting various bioactivities, they provide valuable approved …
Defense contracts: molecular protection in insect-microbe symbioses
Insects cope with environmental threats using a broad array of strategies. A key strategy,
widespread among insects but unappreciated until recently, is the use of molecular …
widespread among insects but unappreciated until recently, is the use of molecular …
Bacteria from the Amycolatopsis genus associated with a toxic bird secrete protective secondary metabolites
Uropygial gland secretions of birds consist of host and bacteria derived compounds and
play a major sanitary and feather-protective role. Here we report on our microbiome studies …
play a major sanitary and feather-protective role. Here we report on our microbiome studies …
The secondary metabolites of rare actinomycetes: chemistry and bioactivity
T Ding, LJ Yang, WD Zhang, YH Shen - RSC advances, 2019 - pubs.rsc.org
Actinomycetes are outstanding and fascinating sources of potent bioactive compounds,
particularly antibiotics. In recent years, rare actinomycetes have had an increasingly …
particularly antibiotics. In recent years, rare actinomycetes have had an increasingly …
Comparative genomics reveals phylogenetic distribution patterns of secondary metabolites in Amycolatopsis species
Background Genome mining tools have enabled us to predict biosynthetic gene clusters that
might encode compounds with valuable functions for industrial and medical applications …
might encode compounds with valuable functions for industrial and medical applications …
The chemical ecology of the fungus-farming termite symbiosis
S Schmidt, S Kildgaard, H Guo… - Natural Product …, 2022 - pubs.rsc.org
Covering: September 1972 to December 2020 Explorations of complex symbioses have
often elucidated a plethora of previously undescribed chemical compounds that may serve …
often elucidated a plethora of previously undescribed chemical compounds that may serve …
Recent progress of antibacterial natural products: Future antibiotics candidates
J Dai, R Han, Y Xu, N Li, J Wang, W Dan - Bioorganic chemistry, 2020 - Elsevier
The discovery of novel antibacterial molecules plays a key role in solving the current
antibiotic crisis issue. Natural products have long been an important source of drug …
antibiotic crisis issue. Natural products have long been an important source of drug …
Chemical mediators at the bacterial-fungal interface
K Scherlach, C Hertweck - Annual Review of Microbiology, 2020 - annualreviews.org
Interactions among microbes are key drivers of evolutionary progress and constantly shape
ecological niches. Microorganisms rely on chemical communication to interact with each …
ecological niches. Microorganisms rely on chemical communication to interact with each …