Green chemistry in the synthesis of pharmaceuticals

S Kar, H Sanderson, K Roy, E Benfenati… - Chemical …, 2021 - ACS Publications
The principles of green chemistry (GC) can be comprehensively implemented in green
synthesis of pharmaceuticals by choosing no solvents or green solvents (preferably water) …

Green metrics in mechanochemistry

N Fantozzi, JN Volle, A Porcheddu, D Virieux… - Chemical Society …, 2023 - pubs.rsc.org
The development of new green methodologies and their broader adoption for promoting
sustainable development in chemistry laboratories and industry play a significant role in …

Mechanochemistry: new tools to navigate the uncharted territory of “impossible” reactions

F Cuccu, L De Luca, F Delogu, E Colacino… - …, 2022 - Wiley Online Library
Mechanochemical transformations have made chemists enter unknown territories, forcing a
different chemistry perspective. While questioning or revisiting familiar concepts belonging …

Sustainability assessment of mechanochemistry by using the twelve principles of green chemistry

KJ Ardila‐Fierro, JG Hernández - ChemSusChem, 2021 - Wiley Online Library
In recent years, mechanochemistry has been growing into a widely accepted alternative for
chemical synthesis. In addition to their efficiency and practicality, mechanochemical …

Mechanochemistry for synthesis

T Friščić, C Mottillo, HM Titi - Angewandte Chemie, 2020 - Wiley Online Library
Mechanochemical solvent‐free reactions by milling, grinding or other types of mechanical
action have emerged as a viable alternative to solution chemistry. Mechanochemistry offers …

Continuous flow mechanochemistry: reactive extrusion as an enabling technology in organic synthesis

RRA Bolt, JA Leitch, AC Jones, WI Nicholson… - Chemical Society …, 2022 - pubs.rsc.org
Rapid and wide-ranging developments have established mechanochemistry as a powerful
avenue in sustainable organic synthesis. This is primarily due to unique opportunities which …

Liquid‐assisted grinding mechanochemistry in the synthesis of pharmaceuticals

P Ying, J Yu, W Su - Advanced Synthesis & Catalysis, 2021 - Wiley Online Library
Mechanochemical reactions by milling, grinding or other types of mechanical action have
emerged as a salient green approach because of its wide applications towards academic …

Tinkering with mechanochemical tools for scale up

JF Reynes, V Isoni, F García - … Chemie International Edition, 2023 - Wiley Online Library
Mechanochemistry provides an environmentally benign platform to develop more
sustainable chemical processes by limiting raw materials, energy use, and waste generation …

Mechanochemistry of gaseous reactants

C Bolm, JG Hernández - Angewandte Chemie International …, 2019 - Wiley Online Library
In recent years, the application of mechanical energy to chemical systems has repeatedly
proven beneficial to facilitate chemical transformations in various areas in chemistry. Today …

Mechanochemistry can reduce life cycle environmental impacts of manufacturing active pharmaceutical ingredients

O Galant, G Cerfeda, AS McCalmont… - ACS Sustainable …, 2022 - ACS Publications
The scale-up of mechanochemical methods could play a transformative role in making
manufacturing processes in the pharmaceutical industry greener by eliminating solvent use …