Self-assembled peptide and protein amyloid nanostructures have traditionally been
considered only as pathological aggregates implicated in human neurodegenerative …

Abstract α-Synuclein is an abundant neuronal protein which localizes predominantly to
presynaptic terminals, and is strongly linked genetically and pathologically to Parkinson's …

Parkinson's disease, the most common age-related movement disorder, is a progressive
neurodegenerative disease with unclear etiology. Key neuropathological hallmarks are …

Physiologically, α-synuclein chaperones soluble NSF attachment protein receptor (SNARE)
complex assembly and may also perform other functions; pathologically, in contrast, α …

Parkinson's disease (PD) is a neurodegenerative disease characterized by a progressive
loss of dopaminergic neurons from the nigrostriatal pathway, formation of Lewy bodies, and …

Abstract α-synuclein is a small protein abundantly expressed in the brain and mainly located
in synaptic terminals. The conversion of α-synuclein into oligomers and fibrils is the hallmark …

Abstract α-synuclein misfolding and aggregation into fibrils is a common feature of α-
synucleinopathies, such as Parkinson's disease, in which α-synuclein fibrils are a …

Assembly of highly curved membrane structures is essential to cellular physiology. The
prevailing view has been that proteins with curvature-promoting structural motifs, such as …

Alpha-Synuclein (α-Syn) is one of the most important molecules involved in the
pathogenesis of Parkinson's disease and related disorders, synucleinopathies, but also in …

Lipid bilayers play an important role in the pathological assembly of amyloidogenic proteins
and peptides. This assembly yields oligomers and fibrils, which are highly toxic protein …