The human connectome in Alzheimer disease—relationship to biomarkers and genetics

M Yu, O Sporns, AJ Saykin - Nature Reviews Neurology, 2021 - nature.com
The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …

Network science of biological systems at different scales: A review

M Gosak, R Markovič, J Dolenšek, MS Rupnik… - Physics of life …, 2018 - Elsevier
Network science is today established as a backbone for description of structure and function
of various physical, chemical, biological, technological, and social systems. Here we review …

Statistical harmonization corrects site effects in functional connectivity measurements from multi‐site fMRI data

M Yu, KA Linn, PA Cook, ML Phillips… - Human brain …, 2018 - Wiley Online Library
Acquiring resting‐state functional magnetic resonance imaging (fMRI) datasets at multiple
MRI scanners and clinical sites can improve statistical power and generalizability of results …

[HTML][HTML] Neuronal excitation/inhibition imbalance: core element of a translational perspective on Alzheimer pathophysiology

F Maestú, W de Haan, MA Busche, J DeFelipe - Ageing Research Reviews, 2021 - Elsevier
Our incomplete understanding of the link between Alzheimer's Disease pathology and
symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies …

Functional connectomics in depression: insights into therapies

Y Chai, YI Sheline, DJ Oathes, NL Balderston… - Trends in Cognitive …, 2023 - cell.com
Depression is a common mental disorder characterized by heterogeneous cognitive and
behavioral symptoms. The emerging research paradigm of functional connectomics has …

Resting-state oscillations reveal disturbed excitation–inhibition ratio in Alzheimer's disease patients

AM Van Nifterick, D Mulder, DJ Duineveld… - Scientific reports, 2023 - nature.com
An early disruption of neuronal excitation–inhibition (E–I) balance in preclinical animal
models of Alzheimer's disease (AD) has been frequently reported, but is difficult to measure …

Synaptic plasticity shapes brain connectivity: implications for network topology

M Stampanoni Bassi, E Iezzi, L Gilio… - International journal of …, 2019 - mdpi.com
Studies of brain network connectivity improved understanding on brain changes and
adaptation in response to different pathologies. Synaptic plasticity, the ability of neurons to …

Clinically approved IVIg delivered to the hippocampus with focused ultrasound promotes neurogenesis in a model of Alzheimer's disease

S Dubey, S Heinen, S Krantic… - Proceedings of the …, 2020 - National Acad Sciences
Preclinical and clinical data support the use of focused ultrasound (FUS), in the presence of
intravenously injected microbubbles, to safely and transiently increase the permeability of …

A comprehensive review of magnetoencephalography (MEG) studies for brain functionality in healthy aging and Alzheimer's disease (AD)

PK Mandal, A Banerjee, M Tripathi… - Frontiers in …, 2018 - frontiersin.org
Neural oscillations were established with their association with neurophysiological activities
and the altered rhythmic patterns are believed to be linked directly to the progression of …

Colloquium: Multiscale modeling of brain network organization

C Presigny, F De Vico Fallani - Reviews of Modern Physics, 2022 - APS
A complete understanding of the brain requires an integrated description of the numerous
scales and levels of neural organization. This means studying the interplay of genes and …