Biological systems are robust to perturbation by mutations and environmental fluctuations.
New data are shedding light on the biochemical and network-level mechanisms responsible …

Organisms rely on mutations to fuel adaptive evolution. However, many mutations impose a
negative effect on fitness. Cells may have therefore evolved mechanisms that affect the …

In the field of mammalian functional genomics, one of the main aims in the post-genomic era
is to elucidate the function of all genes in the genome. The powerful technology of gene …

Phenotypes that vary in response to DNA mutations are essential for evolutionary adaptation
and innovation. Therefore, it seems that robustness, a lack of phenotypic variability, must …

In the last decade vast data sets are being generated in biological and medical studies. The
challenge lies in their summary, complexity reduction, and interpretation. Correlation‐based …

The history of life is a history of evolutionary innovations, qualitatively new phenotypic traits
that endow their bearers with new, often game-changing abilities. We know many individual …

Background The relationship between monogenic and polygenic forms of epilepsy is poorly
understood and the extent to which the genetic and acquired epilepsies share common …

Biologists have long observed that physiological and developmental processes are
insensitive, or robust, to many genetic and environmental perturbations. A complete …

Plants, being sessile organisms, need to respond to changing environments, and as a result
they have evolved unique signalling mechanisms that allow rapid communication between …

Background Individual differences in initial sensitivity to ethanol are strongly related to the
heritable risk of alcoholism in humans. To elucidate key molecular networks that modulate …