Background: The study of tinnitus mechanisms has increased tenfold in the last decade. The
common denominator for all of these studies is the goal of elucidating the underlying neural …

Highlights•The responses of neurons in the auditory cortex (AC) to complex sounds cannot
be predicted based on their responses to tones.•AC tone-evoked responses are shaped by …

In the auditory cortex, synaptic inhibition is known to be involved in sha** receptive fields,
enhancing temporal precision, and regulating gain. Cortical inhibition is provided by local …

Excitation is balanced by inhibition to cortical neurons across a wide range of conditions. To
understand how this relationship is maintained, we broadly suppressed the activity of …

Background Understanding speech in the presence of background noise often becomes
increasingly difficult with age. These age-related speech processing deficits reflect …

An organism's ability to detect and discriminate sensory inputs depends on the recent
stimulus history. For example, perceptual detection thresholds for a brief tone can be …

Auditory neurons are often described in terms of their spectrotemporal receptive fields
(STRFs). These map the relationship between features of the sound spectrogram and firing …

Introduction Both tinnitus and hyperacusis, likely triggered by hearing loss, can be attributed
to maladaptive plasticity in auditory perception. However, owing to their co-occurrence …

Acoustic processing requires integration over time. We have used in vivo intracellular
recording to measure neuronal integration times in anesthetized rats. Using natural sounds …

High dose of salicylate, the active ingredient in aspirin, has long been known to induce
transient hearing loss, tinnitus and hyperacusis making it a powerful experimental tool …