Toxoplasma gondii is an obligate intracellular protozoan parasite which is a significant
human and veterinary pathogen. Other members of the phylum Apicomplexa are also …

A critical factor in the transmission and pathogenesis of Toxoplasma gondii is the ability to
convert from an acute disease-causing, proliferative stage (tachyzoite), to a chronic, dormant …

Apicomplexan parasites exhibit tremendous diversity in much of their fundamental cell
biology, but study of these organisms using light microscopy is often hindered by their small …

The malaria parasite replicates within an intraerythrocytic parasitophorous vacuole (PV).
Eventually, in a tightly regulated process called egress, proteins of the PV and intracellular …

Calcium-regulated exocytosis is a ubiquitous process in eukaryotes, whereby secretory
vesicles fuse with the plasma membrane and release their contents in response to an …

Cyclic GMP (cGMP)-dependent protein kinase (protein kinase G [PKG]) is essential for
microneme secretion, motility, invasion, and egress in apicomplexan parasites, However …

Calcium controls many critical events in the complex life cycles of apicomplexan parasites
including protein secretion, motility, and development. Calcium levels are normally tightly …

Members of Apicomplexa are defined by apical cytoskeletal structures and secretory
organelles, tailored for motility, invasion and egress. Gliding is powered by actomyosin …

Calcium signalling coordinates motility, cell invasion, and egress by apicomplexan
parasites, yet the key mediators that transduce these signals remain largely unknown. One …

To combat drug resistance, new chemical entities are urgently required for use in next
generation anti-malarial combinations. We report here the results of a medicinal chemistry …