[HTML][HTML] Platelet‐based coagulation: different populations, different functions
JWM Heemskerk, NJA Mattheij, J Cosemans - Journal of Thrombosis and …, 2013 - Elsevier
Platelets in a thrombus interact with (anti) coagulation factors and support blood
coagulation. In the concept of cell‐based control of coagulation, three different roles of …
coagulation. In the concept of cell‐based control of coagulation, three different roles of …
Phospholipid signaling in innate immune cells
Phospholipids comprise a large body of lipids that define cells and organelles by forming
membrane structures. Importantly, their complex metabolism represents a highly controlled …
membrane structures. Importantly, their complex metabolism represents a highly controlled …
Mechanics and contraction dynamics of single platelets and implications for clot stiffening
Platelets interact with fibrin polymers to form blood clots at sites of vascular injury,,. Bulk
studies have shown clots to be active materials, with platelet contraction driving the …
studies have shown clots to be active materials, with platelet contraction driving the …
Kinetics and mechanics of clot contraction are governed by the molecular and cellular composition of the blood
Platelet-driven blood clot contraction (retraction) is thought to promote wound closure and
secure hemostasis while preventing vascular occlusion. Notwithstanding its importance, clot …
secure hemostasis while preventing vascular occlusion. Notwithstanding its importance, clot …
Ultrasoft microgels displaying emergent platelet-like behaviours
Efforts to create platelet-like structures for the augmentation of haemostasis have focused
solely on recapitulating aspects of platelet adhesion; more complex platelet behaviours such …
solely on recapitulating aspects of platelet adhesion; more complex platelet behaviours such …
Single-platelet nanomechanics measured by high-throughput cytometry
Haemostasis occurs at sites of vascular injury, where flowing blood forms a clot, a dynamic
and heterogeneous fibrin-based biomaterial. Paramount in the clot's capability to stem …
and heterogeneous fibrin-based biomaterial. Paramount in the clot's capability to stem …
[HTML][HTML] NLRP3 regulates platelet integrin αIIbβ3 outside-in signaling, hemostasis and arterial thrombosis
J Qiao, X Wu, Q Luo, G Wei, M Xu, Y Wu, Y Liu… - …, 2018 - ncbi.nlm.nih.gov
In addition to their hemostatic function, platelets play an important role in regulating the
inflammatory response. The platelet NLRP3 inflammasome not only promotes interleukin-1β …
inflammatory response. The platelet NLRP3 inflammasome not only promotes interleukin-1β …
Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion
C Léon, A Eckly, B Hechler, B Aleil… - Blood, The Journal …, 2007 - ashpublications.org
Mutations in the MYH9 gene encoding the nonmuscle myosin heavy chain IIA result in
bleeding disorders characterized by a macrothrombocytopenia. To understand the role of …
bleeding disorders characterized by a macrothrombocytopenia. To understand the role of …
The role of biophysical properties of provisional matrix proteins in wound repair
Wound healing is a complex, dynamic process required for maintaining homeostasis in an
organism. Along with being controlled biochemically, wound healing is also controlled …
organism. Along with being controlled biochemically, wound healing is also controlled …
Blocking neutrophil integrin activation prevents ischemia–reperfusion injury
Neutrophil recruitment, mediated by β2 integrins, combats pyogenic infections but also plays
a key role in ischemia–reperfusion injury and other inflammatory disorders. Talin induces …
a key role in ischemia–reperfusion injury and other inflammatory disorders. Talin induces …