Cancer development is closely associated with immunosuppressive tumor
microenvironment (TME) that attenuates antitumor immune responses and promotes tumor …

Cancer immunotherapy based on immune-checkpoint inhibition or adoptive cell therapy has
revolutionized cancer care. Nevertheless, a large proportion of patients do not benefit from …

Suppression of antitumor immune responses is one of the main mechanisms by which tumor
cells escape from destruction by the immune system. Myeloid-derived suppressor cells …

Targeting nucleotide metabolism can not only inhibit tumor initiation and progression but
also exert serious side effects. With in-depth studies of nucleotide metabolism, our …

Adoptive cell therapies (ACTs) have existed for decades. From the initial infusion of tumor-
infiltrating lymphocytes to the subsequent specific enhanced T cell receptor (TCR)-T and …

A2A receptors (A2AR), a typical GPCR with a high affinity for adenosine, was expressed in
many immune cells, such as regulatory T cells, cytotoxic T cells, macrophages, etc …

Chronic hepatitis B virus (HBV) infection affects 300 million patients worldwide,, in whom
virus-specific CD8 T cells by still ill-defined mechanisms lose their function and cannot …

Nucleotides are the foundational elements of life. Proliferative cells acquire nutrients for
energy production and the synthesis of macromolecules, including proteins, lipids, and …

Metabolic disorders and abnormal immune function changes occur in tumor tissues and
cells to varying degrees. There is increasing evidence that reprogrammed energy …

Marching into the second decade after the approval of ipilimumab, it is clear that immune
checkpoint inhibitors (ICIs) have dramatically improved the prognosis of melanoma …