The glycocalyx is a polysaccharide structure that protrudes from the body of a cell. It is
primarily conformed of glycoproteins and proteoglycans, which provide communication …

A disintegrin and metalloproteases (ADAMs) are key mediators of cell signaling by
ectodomain shedding of various growth factors, cytokines, receptors and adhesion …

The folding capacity of membrane and secretory proteins in the endoplasmic reticulum (ER)
can be challenged by physiological and pathological perturbations, causing ER stress. If …

Oxytocin, a protein hormone mainly produced by hypothalamus, has been shown to repress
body weight gain in obese animals, in part, by reducing food intake and increasing energy …

The prevalence of NAFLD (non-alcoholic fatty liver disease) is a rapidly increasing problem,
affecting a huge population around the globe. However, CVDs (cardiovascular diseases) …

Aims We previously reported that fenugreek-derived 4-hydroxyisoleucine ameliorates
insulin resistance via regulation of TNF-α converting enzyme (TACE) expression. In the …

Tylosis with oesophageal cancer (TOC) is a rare familial disorder caused by cytoplasmic
mutations in inactive rhomboid 2 (iRhom2 or iR2, encoded by Rhbdf2). iR2 and the related …

Increasing brown adipose tissue (BAT) mass and activation is a therapeutic strategy to treat
obesity and complications. Obese and diabetic patients possess low amounts of BAT, so an …

The origin of the Oxytocin/Vasopressin system dates back about 600 million years. Oxytocin
(Oxt) together with Vasopressin (VP) regulate a diversity of physiological functions that are …

Rhomboid pseudoproteases are catalytically inactive members of the rhomboid superfamily.
The founding members, rhomboids, were first identified in Drosophila as serine …