Aquaporins (AQP) are integral membrane proteins that serve as channels in the transfer of
water, and in some cases, small solutes across the membrane. They are conserved in …

1. Introduction 3621.1 The elusive water pores 3621.2 CHIP28 3622. Studies on AQP-1
3632.1 Expression of AQP1 cDNA in Xenopus oocytes 3632.2 Reconstitution of purified …

The lens-specific water pore aquaporin-0 (AQP0) is the only aquaporin known to form
membrane junctions in vivo. We show here that AQP0 from the lens core, containing some …

The cells of most mammalian organs are connected by groups of cell-to-cell channels called
gap junctions. Gap junction channels are made from the connexin (Cx) family of proteins …

The lens is the largest organ in the body that lacks a vasculature. The reason is simple:
blood vessels scatter and absorb light while the physiological role of the lens is to be …

We determined the x-ray structure of bovine aquaporin 0 (AQP0) to a resolution of 2.2 Å. The
structure of this eukaryotic, integral membrane protein suggests that the selectivity of AQP0 …

Aquaporins (AQPs) or water channels render the lipid bilayer of cell membranes permeable
to water. The numerous AQP subtypes present in any given species, the transport properties …

Single molecule experiments provide insight into the individuality of biological
macromolecules, their unique function, reaction pathways, trajectories and molecular …

Department of Physiology and Biophysics, University of California, Irvine, CA 92697 abstract
Aquaporins facilitate the diffusion of water across cell membranes. We previously showed …

Cataract and presbyopia are the leading cause of vision loss and impaired vision,
respectively, worldwide. Changes in lens biochemistry and physiology with age are …