Cellular senescence is a state of stable, terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells …

Mutations in the TP53 tumour suppressor gene are found in~ 50% of human cancers [,,,,–].
TP53 functions as a transcription factor that directly regulates the expression of~ 500 genes …

A ketogenic diet (KD) is a high-fat, low-carbohydrate diet that leads to the generation of
ketones. While KDs improve certain health conditions and are popular for weight loss …

DNA is strictly compartmentalized within the nucleus to prevent autoimmunity; despite this,
cyclic GMP–AMP synthase (cGAS), a cytosolic sensor of double-stranded DNA, is activated …

The last 40 years have witnessed how p53 rose from a viral binding protein to a central
factor in both stress responses and tumor suppression. The exquisite regulation of p53 …

Abstract p53, which is encoded by the most frequently mutated gene in cancer, TP53, is an
attractive target for novel cancer therapies. Despite major challenges associated with this …

Mutations in the tumor suppressor TP53 cause cancer and impart poor chemotherapeutic
responses, reportedly through loss-of-function, dominant-negative effects and gain-of …

Abstract p53 plays a key role in tumor suppression. The tumor suppressive function of p53
has long been attributed to its ability to induce apoptosis, cell cycle arrest, and senescence …

Abstract p53 is a crucial tumour suppressor that responds to diverse stress signals by
orchestrating specific cellular responses, including transient cell cycle arrest, cellular …

Cellular senescence disables proliferation in damaged cells, and it is relevant for cancer
and aging. Here, we show that senescence occurs during mammalian embryonic …