Chagas disease

A Rassi, JA Marin-Neto - The Lancet, 2010 - thelancet.com
Chagas disease is a chronic, systemic, parasitic infection caused by the protozoan
Trypanosoma cruzi, and was discovered in 1909. The disease affects about 8 million people …

Trypanosoma cruzi genetic diversity: Something new for something known about Chagas disease manifestations, serodiagnosis and drug sensitivity

B Zingales - Acta tropica, 2018 - Elsevier
The genetic diversity of Trypanosoma cruzi, the protozoan agent of Chagas disease, is
widely recognized. At present, T. cruzi is partitioned into seven discrete ty** units (DTUs) …

An Updated View of the Trypanosoma cruzi Life Cycle: Intervention Points for an Effective Treatment

J Martín-Escolano, C Marín, MJ Rosales… - ACS Infectious …, 2022 - ACS Publications
Chagas disease (CD) is a parasitic, systemic, chronic, and often fatal illness caused by
infection with the protozoan Trypanosoma cruzi. The World Health Organization classifies …

Between a bug and a hard place: Trypanosoma cruzi genetic diversity and the clinical outcomes of Chagas disease

LA Messenger, MA Miles, C Bern - Expert review of anti-infective …, 2015 - Taylor & Francis
Over the last 30 years, concomitant with successful transnational disease control programs
across Latin America, Chagas disease has expanded from a neglected, endemic parasitic …

Trypanosoma cruzi surface mucins: host-dependent coat diversity

CA Buscaglia, VA Campo, ACC Frasch… - Nature Reviews …, 2006 - nature.com
The surface of the protozoan parasite Trypanosoma cruzi is covered in mucins, which
contribute to parasite protection and to the establishment of a persistent infection. Their …

Origins of Chagas disease: Didelphis species are natural hosts of Trypanosoma cruzi I and armadillos hosts of Trypanosoma cruzi II, including hybrids

M Yeo, N Acosta, M Llewellyn, H Sánchez… - International journal for …, 2005 - Elsevier
Trypanosoma cruzi, the causative agent of Chagas disease, has at least two principal
intraspecific subdivisions, T. cruzi I (TCI) and T. cruzi II (TCII), the latter containing up to five …

Two Hybridization Events Define the Population Structure of Trypanosoma cruzi

SJ Westenberger, C Barnabé, DA Campbell… - Genetics, 2005 - academic.oup.com
Genetic variation in Trypanosoma cruzi is likely a key determinant in transmission and
pathogenesis of Chagas disease. We have examined nine loci as markers for the extant T …

Trypanosoma Cruzi Genome: Organization, Multi-Gene Families, Transcription, and Biological Implications

A Herreros-Cabello, F Callejas-Hernández, N Gironès… - Genes, 2020 - mdpi.com
Chagas disease caused by the parasite Trypanosoma cruzi affects millions of people.
Although its first genome dates from 2005, its complexity hindered a complete assembly and …

Immunoregulatory networks in human C hagas disease

WO Dutra, CAS Menezes, LMD Magalhães… - Parasite …, 2014 - Wiley Online Library
Chagas disease, caused by the infection with T rypanosoma cruzi, is endemic in all L atin A
merica. Due to the increase in population migration, C hagas disease has spread worldwide …

Chagas disease diagnostic applications: present knowledge and future steps

V Balouz, F Agüero, CA Buscaglia - Advances in parasitology, 2017 - Elsevier
Chagas disease, caused by the protozoan Trypanosoma cruzi, is a lifelong and debilitating
illness of major significance throughout Latin America and an emergent threat to global …