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Cuproptosis: mechanisms and links with cancers
J ** of the human mitochondrial intermembrane space in live cells via ratiometric APEX tagging
Obtaining complete protein inventories for subcellular regions is a challenge that often limits
our understanding of cellular function, especially for regions that are impossible to purify and …
our understanding of cellular function, especially for regions that are impossible to purify and …
Copper metallochaperones
NJ Robinson, DR Winge - Annual review of biochemistry, 2010 - annualreviews.org
The current state of knowledge on how copper metallochaperones support the maturation of
cuproproteins is reviewed. Copper is needed within mitochondria to supply the CuA and …
cuproproteins is reviewed. Copper is needed within mitochondria to supply the CuA and …
Coordination chemistry of copper proteins: how nature handles a toxic cargo for essential function
JT Rubino, KJ Franz - Journal of inorganic biochemistry, 2012 - Elsevier
Biological copper is coordinated predominantly by just three ligand types: the side chains of
histidine, cysteine, and methionine, with of course some exceptions. The arrangement of …
histidine, cysteine, and methionine, with of course some exceptions. The arrangement of …
A novel role for copper in Ras/mitogen-activated protein kinase signaling
ML Turski, DC Brady, HJ Kim, BE Kim… - … and cellular biology, 2012 - Taylor & Francis
Copper (Cu) is essential for development and proliferation, yet the cellular requirements for
Cu in these processes are not well defined. We report that Cu plays an unanticipated role in …
Cu in these processes are not well defined. We report that Cu plays an unanticipated role in …
The mitochondrion: a central architect of copper homeostasis
All known eukaryotes require copper for their development and survival. The essentiality of
copper reflects its widespread use as a co-factor in conserved enzymes that catalyze …
copper reflects its widespread use as a co-factor in conserved enzymes that catalyze …
A Targetable Fluorescent Sensor Reveals That Copper-Deficient SCO1 and SCO2 Patient Cells Prioritize Mitochondrial Copper Homeostasis
We present the design, synthesis, spectroscopy, and biological applications of Mitochondrial
Coppersensor-1 (Mito-CS1), a new type of targetable fluorescent sensor for imaging …
Coppersensor-1 (Mito-CS1), a new type of targetable fluorescent sensor for imaging …