Fatty acid trafficking in cells affects many aspects of cellular function3). Fatty acids act both
as an energy source and as signals for metabolic regulations including gene expression …

Over the past decade, evidences of an integration of metabolic and inflammatory pathways,
referred to as metaflammation in several aspects of metabolic syndrome, have been …

The metabolism of nutrient substrates, including glucose, glutamine, and fatty acids,
provides acetyl-CoA for the tricarboxylic acid cycle to generate energy, as well as …

Oxygen therapy is common during the neonatal period to improve survival, but it can
increase the risk of oxygen toxicity. Hyperoxia can damage multiple organs and systems in …

Over the past decade, a large body of evidence has emerged demonstrating an integration
of metabolic and immune response pathways. It is now clear that obesity and associated …

Introduction Pulmonary hypertension secondary to left heart disease (PH-LHD) is a common
and fatal disease. However, no effective therapeutic targets have been identified. Objectives …

Rationale: Bronchopulmonary dysplasia (BPD) is a major complication of premature birth.
Risk factors for BPD are complex and include prenatal infection and O2 toxicity. BPD …

Angiotensin converting enzyme 2 (ACE2) is the putative functional receptor for severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Current literature on the abundance and …

Neovascularization of the airways occurs in several inflammatory lung diseases, including
asthma. Vascular endothelial growth factor (VEGF) plays an important role in vascular …

Animal models demonstrate that exposure to supraphysiological oxygen during the neonatal
period compromises both lung and pulmonary vascular development, resulting in a …