The dramatic global rise of MDR and XDR Enterobacterales in human medicine forced
clinicians to the reintroduction of colistin as last-resort drug. Meanwhile, colistin is used in …

Polymyxins are well-established antibiotics that have recently regained significant interest
as a consequence of the increasing incidence of infections due to multidrug-resistant Gram …

Colistin is an effective antibiotic for treatment of most multidrug-resistant Gram-negative
bacteria. It is used currently as a last-line drug for infections due to severe Gram-negative …

Klebsiella pneumoniae is one of the most clinically relevant species in immunocompromised
individuals responsible for community-acquired and nosocomial infections, including …

The emergence of carbapenem-resistant Gram-negative pathogens poses a serious threat
to public health worldwide. In particular, the increasing prevalence of carbapenem-resistant …

Polymyxins have recently been re-introduced into the therapeutic arsenal to combat
infections caused by multidrug-resistant Gram-negative bacteria. However, the emergence …

Colistin, also referred to as polymyxin E, is an effective antibiotic against most multidrug-
resistant Gram-negative bacteria and is currently used as a last-line drug for treating severe …

Plasmid-borne colistin resistance mediated by mcr-1 may contribute to the dissemination of
pan-resistant Gram-negative bacteria. Here, we show that mcr-1 confers resistance to …

Antimicrobial-resistant Klebsiella pneumoniae (Kp) has emerged as a major global public
health problem. While resistance can occur across a broad range of Kp clones, a small …

Klebsiella pneumoniae is an important cause of multidrug‐resistant infections worldwide.
Recent studies highlight the emergence of multidrug‐resistant K. pneumoniae strains which …