Proteins are major building blocks of life. The protein content of a cell and an organism
provides key information for the understanding of biological processes and disease. Despite …

Proteins are responsible for the occurrence and treatment of many diseases, and therefore
protein sequencing will revolutionize proteomics and clinical diagnostics. Biological …

Herein, a single biomolecule is imaged by electrochemiluminescence (ECL) using Ru (bpy)
32+-doped silica/Au nanoparticles (RuDSNs/AuNPs) as the ECL nanoemitters. The ECL …

The inability to make broad, minimally biased measurements of a cell's proteome stands as
a major bottleneck for understanding how gene expression translates into cellular …

Through manipulating fluids using microfabricated channeland chamber structures,
microfluidics is a powerful tool to realize high sensitive, high speed, high throughput, and …

Recent advances in cellular profiling have demonstrated substantial heterogeneity in the
behaviour of cells once deemed'identical', challenging fundamental notions of …

Background In recent years, there has been a surge in the development and application of
single-cell genomics, transcriptomics, proteomics, and metabolomics. The metabolome is …

Conspectus Biosensors for highly sensitive, selective, and rapid quantification of specific
biomolecules make great contributions to biomedical research, especially molecular …

Cellular heterogeneity that arises from stochastic expression of genes, proteins and
metabolites is a fundamental principle of cell biology, but single cell analysis has been …

Single-cell analysis is critical to revealing cell-to-cell heterogeneity that would otherwise be
lost in ensemble analysis. Detailed lipidome characterization for single cells is still far from …