THE PAST TWO DECADES have brought remarkable progress in our understanding of the
molecular basis of hemophilia A. This disease, which has already been documented as a …

The physiological protection against bleeding is secured by platelet adhesion to the site of
injury and sealing of the defect. The first step involves the arrest of platelets that have …

Human factor VIII is a plasma glycoprotein that has a critical role in blood coagulation,.
Factor VIII circulates as a complex with von Willebrand factor. After cleavage by thrombin …

The interaction of factor VIII (FVIII) with von Willebrand Factor (VWF) is of direct clinical
significance in the diagnosis and treatment of patients with haemophilia A and von …

In the present study, we found that catabolism of coagulation factor VIII (fVIII) is mediated by
the low density lipoprotein receptor-related protein (LPR), a liver multiligand endocytic …

Abstract von Willebrand factor (VWF) is amongst others synthesized by endothelial cells and
stored as ultra-large (UL) VWF multimers in Weibel-Palade bodies. Although UL-VWF is …

Background—The pathogenesis of unstable angina and non–Q-wave myocardial infarction
is still poorly understood, and early evaluation of prognosis remains difficult. We therefore …

A binding site for von Willebrand factor (vWf) was previously localized to the carboxyl
terminus of the C2 domain of the light chain (LCh) of factor VIII (fVIII). The acidic region of the …

Human factor VIII and factor VIIIa were proteolytically inactivated by activated protein C.
Cleavages occurred within the heavy chain (contiguous A1-A2-B domains) of factor VIII and …

Von Willebrand factor (vWF) pIays a key role in platelel adhesion, thrombus formation and
coagulation, the latter as carrier protein for factor VIII (F VIII). Its abnormalities lead to von …