Background Chlamydiaceae are a family of obligate intracellular pathogens causing a wide
range of diseases in animals and humans, and facing unique evolutionary constraints not …

C. trachomatis, an obligate intracellular bacterium, is the commonest sexually transmitted
infection worldwide and is associated with reproductive pathology. To develop rational …

We recently demonstrated by in vitro experiments that PLGA (poly D, L-lactide-co-glycolide)
potentiates T helper 1 (Th1) immune responses induced by a peptide derived from the …

Abstract Development of a Chlamydia trachomatis vaccine has been a formidable task partly
because of an ineffective delivery system. Our laboratory has generated a recombinant …

Miscarriage affects~ 20% of pregnancies and maternal infections account for~ 15% of early
miscarriages. Chlamydia trachomatis (Ct) has been associated with miscarriage but the …

The study aimed to elucidate role of Th1/Th2/Th17 cytokines in the immunopathogenesis of
spontaneous abortion in Chlamydia trachomatis (Ct)-positive first-trimester aborters …

Develo** a vaccine against Chlamydia is key to combating widespread mortalities and
morbidities associated with this infection in koalas (Phascolarctos cinereus). In previous …

Background Chlamydia trachomatis infection results in reproductive damage in some
women. The process and factors involved in this immunopathology are not well understood …

Interferon gamma (IFNγ) is a key Th1 cytokine, with a principal role in the immune response
against intracellular organisms such as Chlamydia. Along with being responsible for …

Lymphogranuloma venereum (LGV) is a human sexually transmitted disease caused by the
obligate intracellular bacterium Chlamydia trachomatis (serovars L1–L3). LGV clinical …