The prognostication of colorectal cancer (CRC) has traditionally relied on staging as defined
by the Union for International Cancer Control (UICC) and American Joint Committee on …

Colorectal cancer (CRC) is a disease with complex pathogenesis, it is prone to metastasis,
and its development involves abnormalities in multiple signaling pathways. Surgery …

A key aspect of nutrient absorption is the exquisite division of labour across the length of the
small intestine, with individual nutrients taken up at different proximal: distal positions. For …

The intestine is a vital organ responsible for nutrient absorption, bile and waste excretion,
and a major site of host immunity. In order to keep up with daily demands, the intestine has …

Immortal spheroids were generated from fetal mouse intestine using the culture system
initially developed to culture organoids from adult intestinal epithelium. Spheroid proportion …

Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) represent two classes of
important non-coding RNAs in eukaryotes. Although these non-coding RNAs have been …

Cancers of the same tissue-type but in anatomically distinct locations exhibit different
molecular dependencies for tumorigenesis. Proximal and distal colon cancers exemplify …

The mammalian intestinal epithelium has a unique organization in which crypts harboring
stem cells produce progenitors and finally clonal populations of differentiated cells …

The endoderm gives rise to the lining of the esophagus, stomach and intestines, as well as
associated organs. To generate a functional intestine, a series of highly orchestrated …

Adult stem cells maintain regenerative tissue structure and function by producing tissue-
specific progeny, but the factors that preserve their tissue identities are not well understood …