Hydrogel is a type of versatile platform with various biomedical applications after rational
structure and functional design that leverages on material engineering to modulate its …

Hydrogels have been utilized in regenerative applications for many decades because of
their biocompatibility and similarity in structure to the native extracellular matrix. Initially …

In this review, we highlight the importance of nanostructure of cellulose-based biomaterials
to allow cellular adhesion, the contribution of nanostructure to macroscale mechanical …

Organoids are 3D cell culture systems that mimic some of the structural and functional
characteristics of an organ. Organoid cultures provide the opportunity to study organ-level …

Natural extracellular matrices (ECMs) are viscoelastic and exhibit stress relaxation.
However, hydrogels used as synthetic ECMs for three-dimensional (3D) culture are typically …

Many extracellular matrices (ECMs) have a filamentous architecture, which influences cell
growth and phenotype and imparts tissues with specific properties. Man-made fibrillar …

Biointerfaces mediate safe and efficient cell manipulation, which is essential for biomedical
innovations in advanced therapies and diagnostics. The biointerface established by vertical …

With the gradual demographic shift toward an aging and obese society, an increasing
number of patients are suffering from bone and cartilage injuries. However, conventional …

Studies of cellular mechanotransduction have converged upon the idea that cells sense
extracellular matrix (ECM) elasticity by gauging resistance to the traction forces they exert on …

Stem cells respond to nanoscale surface features, with changes in cell growth and
differentiation mediated by alterations in cell adhesion. The interaction of nanotopographical …