Background and Purpose: Population-wide reductions in cardiovascular disease incidence
and mortality have not been shared equally by African Americans. The burden of …

Fibrinogen is an abundant protein synthesized in the liver, present in human blood plasma
at concentrations ranging from 1.5-4 g/L in healthy individuals with a normal half-life of 3-5 …

Venous thromboembolism (VTE), the third leading cause of cardiovascular mortality, is a
complex thrombotic disorder with environmental and genetic determinants. Although several …

At a workshop to update the science linking saturated fatty acid (SAFA) consumption with the
risk of coronary heart disease (CHD) and ischemic stroke, invited participants presented …

Background To overcome the concerns associated with the use of fibrates, pemafibrate (K-
877), a novel selective peroxisome proliferator-activated receptor modulator, was …

Cardiovascular diseases (CVDs) have diverse physiopathological mechanisms with
interconnected oxidative stress and inflammation as one of the common etiologies which …

Epidemiological research over the last 50 years has discovered a plethora of biomarkers
(including molecules, traits or other diseases) that associate with coronary artery disease …

Subcutaneous adipose tissue stores excess lipids and maintains energy balance. We
performed expression quantitative trait locus (eQTL) analyses by using abdominal …

Circulating levels of glycine have previously been associated with lower incidence of
coronary heart disease (CHD) and type 2 diabetes (T2D) but it remains uncertain if glycine …

Mitochondria (MT), the major site of cellular energy production, are under dual genetic
control by 37 mitochondrial DNA (mtDNA) genes and numerous nuclear genes (MT-nDNA) …