Compounds with a nitrobenzoxadiazole (NBD) skeleton exhibit prominent useful properties
including environmental sensitivity, high reactivity toward amines and biothiols (including …

VAP-A is a major endoplasmic reticulum (ER) receptor that allows this organelle to engage
numerous membrane contact sites with other organelles. One highly studied example is the …

Phosphatidylserine (PS) is a negatively charged phospholipid that displays a highly uneven
distribution within cellular membranes, essential for establishment of cell polarity and other …

Lipids are amphiphilic molecules that self-assemble to form biological membranes.
Thousands of lipid species coexist in the cell and, once combined, define organelle identity …

ORPphilins are bioactive natural products that strongly and selectively inhibit the growth of
some cancer cell lines and are proposed to target intracellular lipid-transfer proteins of the …

Lipid transfer proteins (LTPs) are key players in cellular homeostasis and regulation, as they
coordinate the exchange of lipids between different cellular organelles. Despite their …

Lipid biosensors are molecular tools used both in vivo and in vitro applications, capable of
selectively detecting specific types of lipids in biological membranes. However, despite their …

Lipids are precisely distributed in the eukaryotic cell where they help to define organelle
identity and function, in addition to their structural role. Once synthesized, many lipids must …

Osh6 and Osh7 are lipid transfer proteins (LTPs) that move phosphatidylserine (PS) from the
endoplasmic reticulum (ER) to the plasma membrane (PM). High PS levels at the PM are …

ER-plasma membrane (PM) contacts are proposed to be held together by distinct families of
tethering proteins, which in yeast include the VAP homologues Scs2/22, the extended …