Background Cepharanthine (CEP) is a drug used in Japan since the 1950s to treat a
number of acute and chronic diseases, including treatment of leukopenia, snake bites …

Cancer chemotherapy is frequently hampered by drug resistance. Concepts to combine
anticancer drugs with different modes of action to avoid the development of resistance did …

Simple Summary The plant Nelumbo nucifera (Gaertn.), commonly known as lotus, sacred
lotus, Indian lotus, water lily, or Chinese water lily, is an aquatic perennial crop belonging to …

Background Oxidative stress-induced endothelial dysfunction and pyroptosis play an
important role during chronic kidney disease (CKD) progression. Neferine, which is an …

Most organs in the body rely on blood flow, and vesicular damage is the leading cause of
injury in multiple organs. The endothelium, as the barriers of vessels, play a critical role in …

Cepharanthine is an active ingredient separated and extracted from Stephania cepharantha
Hayata, a Menispermaceae plant. As a bisbenzylisoquinoline alkaloid, cepharanthine has …

Background Endometrial cancer (EC) as one of the most prevalent malignancies in the
female reproductive system, usually has a poor diagnosis and unfavorable health effects …

Drug resistance is still an obstacle in cancer therapy, leading to the failure of tumor
treatment. The emergence of tumor drug resistance has always been a main concern of …

Although cisplatin is one of the most common antineoplastic drug, its successful utilisation in
cancer treatment is limited by the drug resistance. Multiple attempts have been made to find …

This article recapitulates the existing in vitro and in vivo studies focusing on the effects of
neferine-an alkaloid derivative of lotus plant, in various disease models and its effects on …