PodoSighter: a cloud-based tool for label-free podocyte detection in kidney whole-slide images
Background Podocyte depletion precedes progressive glomerular damage in several kidney
diseases. However, the current standard of visual detection and quantification of podocyte …
diseases. However, the current standard of visual detection and quantification of podocyte …
NAD deficiency contributes to progressive kidney disease in HIV-nephropathy mice
HIV disease remains prevalent in the United States and is particularly prevalent in sub-
Saharan Africa. Recent investigations revealed that mitochondrial dysfunction in kidney …
Saharan Africa. Recent investigations revealed that mitochondrial dysfunction in kidney …
Variant APOL1 protein in plasma associates with larger particles in humans and mouse models of kidney injury
M Andrews, T Yoshida, CM Henderson, H Pflaum… - PloS one, 2022 - journals.plos.org
Background Genetic variants in apolipoprotein L1 (APOL1), a protein that protects humans
from infection with African trypanosomes, explain a substantial proportion of the excess risk …
from infection with African trypanosomes, explain a substantial proportion of the excess risk …
Biologically informed clot histomics are predictive of acute ischemic stroke etiology
Background Toward development of diagnostics for cryptogenic stroke, we hypothesize that
histomic features of stroke blood clots retrieved by mechanical thrombectomy could be used …
histomic features of stroke blood clots retrieved by mechanical thrombectomy could be used …
[HTML][HTML] APOL1 kidney risk variants in glomerular diseases modeled in transgenic mice
APOL1 high-risk variants partially explain the high kidney disease prevalence among
African ancestry individuals. Many mechanisms have been reported in cell culture models …
African ancestry individuals. Many mechanisms have been reported in cell culture models …
Tectonic infarct analysis: A computational tool for automated whole-brain infarct analysis from TTC-stained tissue
Background Infarct volume measured from 2, 3, 5-triphenyltetrazolium chloride (TTC)-
stained brain slices is critical to in vivo stroke models. In this study, we developed an …
stained brain slices is critical to in vivo stroke models. In this study, we developed an …
PKR activation-induced mitochondrial dysfunction in HIV-transgenic mice with nephropathy
HIV disease remains prevalent in the USA and chronic kidney disease remains a major
cause of morbidity in HIV-1-positive patients. Host double-stranded RNA (dsRNA)-activated …
cause of morbidity in HIV-1-positive patients. Host double-stranded RNA (dsRNA)-activated …
Single-Cell Transcriptional Signatures of Glomerular Disease in Transgenic Mice with APOL1 Variants
Background APOL1 high-risk variants contribute to kidney disease among African-ancestry
individuals. We sought to describe cell-specific APOL1 variants-induced pathways using two …
individuals. We sought to describe cell-specific APOL1 variants-induced pathways using two …
NAD+ activates renal metabolism and protects from chronic kidney disease in a model of Alport syndrome
Chronic kidney disease (CKD) is associated with renal metabolic disturbances, including
impaired fatty acid oxidation (FAO). Nicotinamide adenine dinucleotide (NAD+) is a small …
impaired fatty acid oxidation (FAO). Nicotinamide adenine dinucleotide (NAD+) is a small …
[ΒΙΒΛΙΟ][B] Radiographic Biomarkers for Acute Ischemic Stroke Management
TR Patel - 2022 - search.proquest.com
Acute ischemic stroke (AIS) is caused when a clot formed within the circulatory system
travels to the brain to occlude one of the major arteries supplying blood to the brain tissue …
travels to the brain to occlude one of the major arteries supplying blood to the brain tissue …