Regulating tumor suppressor genes: post-translational modifications

L Chen, S Liu, Y Tao - Signal transduction and targeted therapy, 2020 - nature.com
Tumor suppressor genes cooperate with each other in tumors. Three important tumor
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …

Targeting epigenetics for cancer therapy

JW Park, JW Han - Archives of pharmacal research, 2019 - Springer
Cancer can be identified as a chaotic cell state, which breaks the rules that govern growth
and reproduction, with main characteristics such as uncontrolled division, invading other …

Signaling, metabolism, and cancer: An important relationship for therapeutic intervention

M Vaghari‐Tabari, GA Ferns, D Qujeq… - Journal of cellular …, 2021 - Wiley Online Library
In cancerous cells, significant changes occur in the activity of signaling pathways affecting a
wide range of cellular activities ranging from growth and proliferation to apoptosis …

Multi-omics research strategies in ischemic stroke: a multidimensional perspective

W Li, C Shao, H Zhou, H Du, H Chen, H Wan… - Ageing research reviews, 2022 - Elsevier
Ischemic stroke (IS) is a multifactorial and heterogeneous neurological disorder with high
rate of death and long-term impairment. Despite years of studies, there are still no stroke …

Current paradigms in epigenetic anticancer therapeutics and future challenges

M Singh, V Kumar, N Sehrawat, M Yadav… - Seminars in cancer …, 2022 - Elsevier
Any alteration at the genetic or epigenetic level, may result in multiplex of diseases including
tumorigenesis which ultimately results in the cancer development. Restoration of the normal …

Oncogenes and tumor suppressor genes: functions and roles in cancers

TC Dakal, B Dhabhai, A Pant, K Moar… - MedComm, 2024 - Wiley Online Library
Cancer, being the most formidable ailment, has had a profound impact on the human health.
The disease is primarily associated with genetic mutations that impact oncogenes and tumor …

Melatonin and its role in the epithelial-to-mesenchymal transition (EMT) in cancer

C Martínez-Campa, V Álvarez-García… - Cancers, 2024 - mdpi.com
Simple Summary The epithelial-to-mesenchymal transition (EMT) is a process taking place
during carcinogenesis. The phenotypic changes include the acquisition of new properties …

[HTML][HTML] Natural products targeting the p53-MDM2 pathway and mutant p53: recent advances and implications in cancer medicine

JJ Qin, X Li, C Hunt, W Wang, H Wang, R Zhang - Genes & diseases, 2018 - Elsevier
The p53 tumor suppressor plays a major role in controlling the initiation and development of
cancer by regulating cell cycle arrest, apoptosis, senescence, and DNA repair. The MDM2 …

Mechanisms of tumor immunosuppressive microenvironment formation in esophageal cancer

XJ Zhang, Y Yu, HP Zhao, L Guo… - World Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
As a highly invasive malignancy, esophageal cancer (EC) is a global health issue, and was
the eighth most prevalent cancer and the sixth leading cause of cancer-related death …

Marine algae‐derived characterized bioactive compounds as therapy for cancer: A review on their classification, mechanism of action, and future perspectives

W Liao, Y Chen, S Shan, Z Chen, Y Wen… - Phytotherapy …, 2024 - Wiley Online Library
In 2022, there were around 20 million new cases and over 9.7 million cancer‐related deaths
worldwide. An increasing number of metabolites with anticancer activity in algae had been …