Orthodontic tooth movement relies on coordinated tissue resorption and formation in the
surrounding bone and periodontal ligament. Tooth loading causes local hypoxia and fluid …

Soft connective tissues at steady state are dynamic; resident cells continually read
environmental cues and respond to them to promote homeostasis, including maintenance of …

Tissue fibrosis and extracellular matrix (ECM) stiffening promote tumour progression. The
mechanisms by which ECM regulates its contacting cells have been extensively studied …

Tissue development is orchestrated by the coordinated activities of both chemical and
physical regulators. While much attention has been given to the role that chemical regulators …

Cell migration toward areas of higher extracellular matrix (ECM) rigidity via a process called"
durotaxis" is thought to contribute to development, immune response, and cancer …

The ability of cells to sense and respond to mechanical signals is vital in development and
healthy tissue functioning. Many diseases are related to either changing mechanical …

Simple Summary The cytoskeleton is a network of protein fibres within cells that provide
structure and support intracellular transport. Focal adhesions are protein complexes …

Non-muscle myosin II (NM II) is an actin-binding protein that has actin cross-linking and
contractile properties and is regulated by the phosphorylation of its light and heavy chains …

The cells and tissues of the human body are constantly exposed to exogenous and
endogenous forces that are referred to as biomechanical cues. They guide and impact …

Cells within tissues are continuously exposed to physical forces including hydrostatic
pressure, shear stress, and compression and tension forces. Cells dynamically adapt to …