As direct effector cells for osteogenesis, osteoblastic cells are commonly used for evaluating
the in vitro osteogenic capacity of bone biomaterials, and the traditional biological principle …

The bone is an essential organ for locomotion and protection of the body, as well as
hematopoiesis and mineral homeostasis. In order to exert these functions throughout life …

To treat systemic bone loss as in osteoporosis and/or focal osteolysis as in rheumatoid
arthritis or periodontal disease, most approaches target the osteoclasts, the cells that resorb …

Osteoimmunology is at full display during endosseous implant osseointegration. Bone
formation, maintenance and resorption at the implant surface is a result of bidirectional and …

The regulatory role of the immune system in maintaining bone homeostasis and restoring its
functionality, when disturbed due to trauma or injury, has become evident in recent years …

Reproductive hormones play a crucial role in the growth and maintenance of the
mammalian skeleton. Indeed, the biological significance for this hormonal regulation of …

The osteoimmunomodulatory property of bone biomaterials is a vital property determining
the in vivo fate of the implants. Endowing bone biomaterials with favorable …

Among the numerous molecules that are being studied for their potential utility as
biomarkers of cardiovascular diseases, much interest has been shown in the superfamily of …

Osteoporosis, characterized by deteriorated bone microarchitecture and low bone mineral
density, is a chronic skeletal disease with high worldwide prevalence. Osteoporosis related …

The field of cell therapy and regenerative medicine can hold the promise of restoring normal
tissues structure and function. Additionally, the main targets of stem cell-based therapies are …